瘦素对骨质疏松症效应的研究进展  

The development of leptin's effects on the osteoporosis research

作　　者：吴岩[1] 许应星[1] 肖鲁伟[1] 童培建[1] 吴承亮[1] 

机构地区：[1]浙江中医药大学第一临床医学院,杭州310053

出　　处：《中国骨质疏松杂志》2010年第5期377-380,共4页Chinese Journal of Osteoporosis

摘　　要：瘦素作为一种内分泌激素,通过中枢和外周两种途径调节骨代谢。瘦素的中枢效应可能是通过下丘脑、交感神经系统以及β受体而最终引起骨量减少,瘦素的外周效应可能是通过骨髓基质细胞,骨化细胞和破骨细胞3个方面起作用并最终引起骨量增加。瘦素对骨代谢的整体作用可能取决于血清瘦素的水平及血脑屏障的通透性。As an endocrine hormone, leptin regulators bone metabolism through the central way and peripheral way. The central effect of leptin causes bone loss possibly through the hypothalamus, the sympathetic nervous system and β-adrenergie receptor, The peripheral effects of leptin can increased bone mass possibly by bone marrow stromal cells, ossification cells and osteoelasts. The orerall role of leptin on the bone metabolism may be depended on the level of serum leptin and the permeability of blood-cerebral barrier.

关 键 词：瘦素 骨代谢 中枢效应 外周效应 

分 类 号：R589.9[医药卫生—内分泌]