养血生发胶囊对C57BL/6小鼠毛发生长的影响及机制  

The effect and mechanism of Yangxue Shengfa Capsules on hair growth in mice

作　　者：陈芙蓉[1] 岳南[1] 只德广[1] 赵益桂[1] 

机构地区：[1]天津药物研究院新药评价中心,天津300193

出　　处：《现代药物与临床》2010年第2期137-140,共4页Drugs & Clinic

摘　　要：目的观察养血生发胶囊对C57BL/6小鼠毛发生长的影响,并探讨其可能的作用机制。方法采用C57BL/6小鼠脱发实验模型,观察毛发生长情况,并于脱毛后第9、19天,做脱毛区皮肤毛囊数、毛细血管数及毛囊血管内皮生长因子(VEGF)检测。结果养血生发胶囊明显缩短小鼠皮肤变黑时间;明显增加皮肤毛囊数、毛囊毛细血管数及毛囊组织中VEGF表达积分吸光度(A)值。结论养血生发胶囊通过增加毛囊组织中VEGF表达、毛囊血管数及毛囊数,促进毛发生长。Objective To investigate the effect of Yangxue Shengfa Capsules on hair growth of mice, and to detect the possible mechanism of hair growth promotion by using vascular endothelial growth factor （VEGF）. Methods C57BL/6 mice were chosen as experimental animals. Hair re-growth was observed, and the number of hair follicles, capillary and VEGF in hairless zone were determined on 9 and 19 clay after the depilation. Results Yangxue Shengfa Capsules shortened significantly the time of skin darkening. Compared with model group, there was significant increase in hair follicle number and skin blood vessels as well as the integrated optical density （A） of VEGF in Yangxue Shengfa group. Conclusion Yangxue Shengfa Capsules can promote hair growth by increasing A of VEGF, hair follicle number and skin blood vessels.

关 键 词：养血生发胶囊 毛发生长 血管内皮生长因子 毛囊 

分 类 号：R282.5[医药卫生—中药学]