三聚氰胺亚急性经口染毒大鼠后肾与膀胱组织病理学研究  

Histopathological changes of urinary bladders and kidneys of rats with oral administration of melamine

作　　者：徐新云[1] 陶功华[1] 吴德生[1] 周丽[1] 袁建辉[1] 蒋英芝[1] 郑波[1] 李学余[1] 

机构地区：[1]深圳市疾病预防控制中心,广东518020

出　　处：《中国预防医学杂志》2010年第5期459-461,共3页Chinese Preventive Medicine

基　　金：深圳市科技计划项目资助课题(200902091)

摘　　要：目的探讨三聚氰胺亚急性经口染毒对大鼠肾和膀胱等组织的病理学改变。方法用三聚氰氨对SD大鼠进行亚急性经口染毒实验,雌雄大鼠各设1个对照组和3个实验组,每组10只大鼠,每天对动物采用经口灌胃染毒1次,染毒时间28 d,实验结束时取动物肾、膀胱、心、肝、脾、肺组织进行病理学检查。结果3个三聚氰胺实验组可见部分动物出现肾小管透明管型,高剂量组膀胱组织可见黏膜下水肿、血管扩张,局部可见黏膜上皮脱落,部分膀胱组织可见膀胱内沉积物。结论本研究显示三聚氰胺对大鼠肾脏和膀胱产生一定的毒性作用。Objective To explore the pathological changes of urinary system in rats after oral administration of melamine for 28 days.Methods Forty male and female SD rats each were evenly divided into control,low,medium and high dose melamine treatment groups..Histopathological examination was performed for kidneys,bladders,hearts,livers and lungs of rats after 28 days of the melamine treatment.Results Transparent tubular cylinders were observed in three experimental groups.The pathological changes also included submucosal edema,hemangiectasis and exuviations in some local areas of mucosa,and sediments in bladders of rats with the oral administration of high dose of melamine.Conclusion Melamine could produce subacute pathological changes in the kidneys and bladders of rats when the animals were treated with oral administration of melamine.

关 键 词：三聚氰胺 亚急性试验 毒性 大鼠 病理 

分 类 号：R114[医药卫生—卫生毒理学]