The potential role of kinesin and dynein in Golgi scattering and cytoplasmic vacuole formation during acute experimental pancreatitis  

作　　者：Ina A Weber Igor Buchwalow Daniela Hahn Wolfram Domschke Markus M Lerch Jtirgen Schnekenburger 

机构地区：[1]Department of Medicine B, Westfalische Wilhelms-University, D-48149 Miinster, Germany [2]Gerhard Domagk lnstitute of Pathology, Westfailische Wilhelms-University, D-48149 Miinster, Germany [3]Department of Medicine A, Ernst-Moritz-Arndt- University, D-17487 Greifswald, Germany

出　　处：《Cell Research》2010年第5期599-602,共4页细胞研究（英文版）

摘　　要：Acute pancreatitis is initiated in pancreatic acinar cells and characterized by a profound disturbance in intracellular vesicle transport. Moreover, secretion of pancreatic zymogens is blocked, paralleled by the formation of cytoplasmic vacuoles with premature protease activation that precedes cellular necrosis and organ damage [1]. An early event triggering the development of acute pancreatitis could be the rapid disassembly of the acinar cell cytoskeleton that has been observed during secretagogueinduced pancreatitis in rodents .

关 键 词：急性胰腺炎 潜在作用 高尔基体 动力蛋白 实验性 细胞质 散射 液泡 

分 类 号：Q244[生物学—细胞生物学] S858.292[农业科学—临床兽医学]