计算机辅助立体定向脑内人视网膜色素上皮细胞移植治疗帕金森病  

Computer-assisted stereotactic transplantation of human retinal pigment epithelium cells in Parkinson disease

作　　者：薛彦忠[1] 任廷文[2] 庞守良[1] 王玉国[1] 姚金国[1] 周建峰[1] 郝培来[1] 徐会厂[1] 

机构地区：[1]临沂市沂水中心医院神经内科,山东省276400 [2]中山医科大学附属医院

出　　处：《中华器官移植杂志》2010年第5期292-295,共4页Chinese Journal of Organ Transplantation

基　　金：基金项目：山东省临沂市科技局计划项目（080103（135）

摘　　要：目的探讨脑内定向人视网膜色素上皮（hRPE）细胞移植治疗帕金森病的临床疗效。方法选择17例原发性帕金森病患者作为研究对象，每例患者均在计算机X线断层扫描（CT）和磁共振成像（MRI）图像融合技术指导下，将4×10^6个hRPE细胞通过立体定向手术移植到症状对侧的脑内壳核后部和侧脑室内。观察移植术后7d、1个月和3个月时的治疗效果。结果患者移植部位的对侧症状在术后即持续改善，术后1和3个月时总有效率均达88．2％，显著有效率为82．4％；移植部位的同侧症状在术后早期有改善的患者，1个月后其有效率明显增加，3个月时总有效率达88．2％，显著有效率为64．7％。除少数患者有一过性头晕和肢体轻瘫外，无其他重大不良反应。结论计算机辅助立体定向脑内hRPE细胞移植治疗帕金森病是安全和有效的。Objective To study the clinical efficacy of computer-assisted stereotactic brain transplantation of human retinal pigment epithelium （hRPE） ceils into the patients with Parkinson disease （PD）. Methods Under the guidance of computed X-ray tomography and magnetic resonance imaging image mergence, 4 ×10^6 hRPE cells were transplanted into the putamen and ventrieulus laterlis of 17 cases of PD by stereotactic surgery. The transplantation sites were contralateral to the side of main symptoms and signs. The curative efficacy were observed at the 7th day, 1st month, and 3rd month after the transplantation. Results The contralateral symptoms were ameliorated continuously after the transplantation. Three months after the surgery, the total effective rate of cell transplantation was 88.2 %, and 82. 4 %of the cases got significant improvement. The cases that got ipsilateral improvement soon after the surgery gave a total effective rate as high as 88.2 % at the 3rd month during follow-up period, and 64. 7 %among these cases improved significantly. Only a minority of cases had transient dizziness and hemiparesis, but the duration was short. Conclusion The therapy, computer-assisted stereotactic transplantation of hRPE cells in the treatment of PD, is safe and efficient.

关 键 词：立体定向技术 细胞移植 图像处理 计算机辅助 帕金森病 

分 类 号：R651.1[医药卫生—外科学]