血浆可溶型人类白细胞抗原-G在系统性红斑狼疮患者中的表达分析  

Analysis of plasma soluble human leukocyte antigen-G levels in patients with systemic lupus erythematosus

作　　者：吴凤霞[1] 武丽君[2] 罗雄燕[1] 杨明辉[1] 库尔班江[2] 刘宁涛[3] 宋小芸[2] 唐中[1] 周京国[1] 袁国华[1] 

机构地区：[1]川北医学院风湿免疫研究所,南充637000 [2]新疆维吾尔自治区人民医院风湿科 [3]四川省遂宁市中心医院风湿科

出　　处：《中华风湿病学杂志》2010年第5期323-325,共3页Chinese Journal of Rheumatology

摘　　要：目的 检测系统性红斑狼疮（SLE）患者血浆可溶性人类白细胞抗原-G（sHLA-G）水平,并分析其与SLE脏器受累及疾病活动性的关系,探讨sHLA-G在SLE发病机制中的可能作用.方法 酶联免疫吸附法（ELISA）检测96例SLE患者血浆sHLA-G水平,并与74名健康体检者对照.采用t检验,直线相关回归方法 和X2检验,P〈0.05为差异有统计学意义.结果血浆sHLA-G水平在SLE患者为（230±192）U/ml;显著高于健康体检者的（118±38）U/ml（t=5.07,P=0.0001）;血浆sHLA-G水平与SLE疾病活动性指数（SLEDIA）无明显相关性（r=0.157,P=0.141）;但血浆sHLA-G水平增高的SLE患者较血浆sHLA-G水平正常患者SLEDAI高（11±5与8±5,P=0.027）,易出现中枢神经系统受累（24.2%与4.8%,P=0.007）.结论 血浆sHLA-G水平增高SLE患者病情较重、中枢神经系统受累较多,提示sHLA-G在SLE病理过程中可能发挥重要作用.Objective To determine plasma soluble HLA-G （sHLA-G） levels in patients with systemic lupus erythematosus （SLE）,and to analyze its association with the possibility of organs or systems involvement in lupus patients.Methods Plasma samples were collected from 96 SLE patients and 74 healthy controls,and sHLA-G levels were determined by enzyme-linked immunosorbent assay.The sHLA-G levels in SLE patients and healthy controls were compared with students＇t-test.The difiefence of clinical and seroimmunological data among the SLE patients was assessed by chi-square test or students＇t-test.A value of P〈0.05 was considered to be significant.Results Plasma concentration of sHLA-G was significanto higher in SLE patients than that in healthy controls[（230±192）U/ml vs（118±38）U/ml,P=0.0001].No relationship between plasma sHLA-G levels and SLE disease activity index（SLEDAI）was found（r=0.157,P=0.141）.However,the patients with increased levels of sHLA-G had more severe disease activity （11±5 vs 8±5,P=0.027） and more central nervous system （CNS） involvement （24.2% vs 4.8%,P=0.007） in comparison with patients with normal plasma levels of sHLA-G.Conclusion The increased production sHLA-G,paralleled with more severe disease activity and higher CNS involvement,indicates that sHLA-G may play an important role in the pathogenesis of SLE.

关 键 词：红斑狼疮 系统性 HLA抗原 

分 类 号：R593.241[医药卫生—内科学]