检测阴道液中胎盘α微球蛋白-1诊断胎膜早破的价值  

Placental alpha-microglobulin-1 in vagina liquid to diagnose premature rupture of membranes

作　　者：郭广玲[1] 刘永珍[1] 张春莲[1] 魏振彤[2] 陈双郧[1] 

机构地区：[1]郧阳医学院附属太和医院妇产科, 湖北十堰442000 [2]吉林大学第一临床医院妇产科

出　　处：《中国医师进修杂志》2010年第15期4-6,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的 探讨定性检测阴道液中胎盘α微球蛋白-1（PAMG-1）诊断胎膜早破的价值.方法 前瞻性对照分析100例有胎膜早破症状和体征患者的阴道液中PAMG-1和传统的诊断方法,并且回顾患者最初及所有后来的鉴定和临床过程后作评价.结果 检测PAMG-1诊断胎膜早破的灵敏度为100%（89/89）,特异度为91%（10/11）,阳性预测值为99%（89/90）,阴性预测值为100%（10/10）,假阳性率为9%（1/11）,灵敏度和阴性预测值明显高于传统的诊断方法,差异有统计学意义（P〈0.01）.结论 检测阴道液PAMG-1对胎膜早破的诊断优于传统的诊断方法.Objective To explore the value of placental alpha-microglobulin-1 in vagina liquid to diagnose premature rupture of membranes. Methods A prospective observational study to initial evaluation included both the standard clinical evaluation for rupture of membranes and placental alpha-microglobulin-1 immunoassay. Rupture of membranes was diagnosed if fluid was seen leaking from the cervical os or if two of the following three conditions were present： pooling of fluid, positive nitrazine test, or feming. Rupture of membranes was diagnosed definitively on review of the medical records after delivery. Results Placental alpha-microglobulin-1 immunoassay confirmed rupture of membranes at initial presentation with a sensitivity of 100% （89/89）, specificity of 91% （10/11）, positive predictive value of 99% （89/90）, and negative predictive value of 100% （10/10）,false positive rate of 9% （1/11）. Placental alpha-nricroglobulin-1 immunoassay was better than the conventional clinical assessment in confirming the diagnosis of rupture ofmembranes （P〈0.01）. Conclusion Measurement of placental alpha-microglobulin-1 in cervicovaginal secretions is superior to conventional clinical assessment in the diagnosis of rupture of membranes.

关 键 词：胎盘 胎膜早破 诊断 α微球蛋白-1 

分 类 号：R714.433[医药卫生—妇产科学]