慢性阻塞性肺疾病患者血清抵抗素和肿瘤坏死因子水平与营养不良的关系  

Relations between serum levels of resistin and tumor necrosis factor-α and malnutrition in patients with chronic obstructive pulmonary disease

作　　者：李杰[1] 刘惟优[1] 赖庆文[1] 曾治平[1] 刘建生[1] 袁平[1] 

机构地区：[1]赣南医学院第一附属医院呼吸科,江西赣州341000

出　　处：《临床荟萃》2010年第11期933-935,共3页Clinical Focus

基　　金：江西省卫生厅立项课题(20083073)

摘　　要：目的探讨慢性阻塞性肺疾病急性加重期(AECOPD)患者血清抵抗素、肿瘤坏死因子α(TNF-α)水平及其与营养状况的关系。方法采用酶联免疫吸附测定(ELISA)方法检测AECOPD患者40例和健康对照者30例血清抵抗素、TNF-α水平,分析相关因素。结果AECOPD组患者血清抵抗素水平低于健康对照组,(3.2±1.9)μg/Lvs(4.2±2.4)μg/L,TNF-α水平高于对照组,(1 505±252)ng/L vs(397±66)ng/L,差异均有统计学意义(P<0.01);AECOPD组营养不良患者抵抗素水平低于非营养不良患者,(2.6±1.8)μg/L vs(3.5±2.1)μg/L(P<0.01)。AECOPD患者抵抗素水平与第1秒用力呼气容积(FEV1)及FEV1/用力肺活量(FVC)、体质量指数(BMI)及胸围、腹围呈显著正相关(r=0.356~0.493,均P<0.01),而TNF-α与FEV1、FEV1/FVC、BMI及胸围、腹围呈显著负相关(r=-0.521^-0.395,均P<0.01)。结论AECOPD患者血清抵抗素水平下降,合并营养不良时下降更加明显,而TNF-α水平则升高,合并营养不良时升高更加明显。Objective To explore the relationship between the nutriture and the expression levels of serum resistin and tumor necrosis factor-α （TNF-α） in the acute exacerbations of chronic obstructive pulmonary disease （AECOPD） patients. Methods ELISA was used to detect the expression levels of serum resistin and TNF-α between 40 AECOPD patients group and 30 healthy people group（control group）. Results The expression of serum resistin was significantly different in the patients group compared with that of control group, （3.2±1.9） μg/L vs （4.2 ±2.4） μg/L （ P d0.01） ,and the expression of TNF-α was higher in patients group compared with that of control group, （1 505± 252） ng/L vs （397 ± 66） ng/L（ P 〈 0.01）. The expression of serum resistin about the malnutritional patients was lower than that of the eutrophy patients, （2.6±1.8） μg/L vs （3.5±2.1） μg/L（P〈0.01）. The level of serum resi,stin in AECOPD patients was positively associated with FEV1,FEV1/FVC,BMI,chest circumference and waistline （ r =0. 356-0. 493,all P d0.01）,while the level of TNF-α was negatively associated with them （ r =0. 521-0. 395, all P 〈0.01）. Conclusion The level of serum resistin decreased in the AECOPD patients group,and decreased more significantly when associated with malnutrition in these patients, while the level of TNF-α raised, and the increase was more significantly when associated with malnutrition.

关 键 词：肺疾病 慢性阻塞性 抵抗素 肿瘤坏死因子Α 营养不良 

分 类 号：R563.9[医药卫生—呼吸系统]