用于疾病诊断的Gd^Ⅲ/量子点多模态成像探针的构建  

Preparation of Gd~Ⅲ/Quantum Dots Multimodal Imaging Probes for Disease Diagnosis

作　　者：张兵波[1] 宫晓群[2] 李卓权[1] 郭方方[1] 蔡少瑜[5] 孔继烈[5] 杨秋花[2] 马浩[2] 常津[1,2] 时东陆[1,3,4] 

机构地区：[1]同济大学先进材料与纳米生物医学研究院,上海200092 [2]天津大学材料学院纳米生物技术研究所,天津300072 [3]辛辛那提大学化学与材料工程系,辛辛那提45221-0012 [4]上海交通大学微纳研究院,上海200240 [5]复旦大学化学系,上海200433

出　　处：《高等学校化学学报》2010年第5期982-985,共4页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:50873076);国家“八六三”重点项目(批准号:2007AA021808);上海纳米专项(批准号:0952nm04800,0852nm03800);同济大学青年优秀人才培养计划(批准号:2009KJ072)资助

摘　　要：结合核磁共振成像(MRI)和荧光成像技术,以钆离子、近红外低毒量子点、二氧化硅和聚丙烯酸(PAA)等为原料,采用一系列纳米载体自组装技术,构建出MRI弛豫率/荧光效率高和生物相容性好的GdⅢ/量子点多模态纳米探针.结果表明,与未螯合GdⅢ的量子点纳米探针相比,GdⅢ/量子点多模态纳米探针具有更高的弛豫率;t1-加权MRI成像也证实了GdⅢ/量子点多模态纳米探针具有很好的阳性造影功效.One of the major challenges in tumor research is early diagnosis in vivo.The current diagnostic methods,such as PET,MRI,and hematology tests,although effective in some aspects of tumor observations,are limited as a result of single functionality.Furthermore,the detection mechanism is often not compatible with the imaging system,making it difficult for accurate diagnosis.In this paper,MRI and fluorescence imaging were combined with several key contrast agents including quantum dots（QDs）,gadolinium ion,silica,and poly（acrylic acid）（PAA） for high relaxation rate,strong fluorescent emission,and good biocompatibility,among which GdⅢ/QDs were utilized for effective multimodal nano-probes.The experimental results from this study indicate a higher relaxation rate of the GdⅢ/QDs multimodal nano-probes than that of silica-coated QDs without GdⅢ.The t1-weighted MRI analysis show that these GdⅢ/QDs based nano-probes can be potentially used for effective multimodal imaging agents.

关 键 词：多模态成像 近红外量子点 核磁共振成像 

分 类 号：Q503[生物学—生物化学] O648[理学—物理化学]