遗尿方对肾阳虚遗尿大鼠抗利尿激素的调节作用  

Study on the changes of serum levels of AVP and the regulatory effects of Yiniao Fang in enuresis model rats

作　　者：苏文[1] 胡爱霞[2] 徐辉甫[1] 杜恒[1] 

机构地区：[1]武汉市中西医结合医院儿科,湖北武汉430022 [2]湖北中医学院中医系硕士207级

出　　处：《中国医院药学杂志》2010年第10期825-827,共3页Chinese Journal of Hospital Pharmacy

基　　金：湖北省卫生厅中西医结合科研项目(编号:鄂卫文[2006]63号)

摘　　要：目的:研究肾阳虚型遗尿大鼠血清抗利尿激素(AVP)的含量变化,以及遗尿方对它的调节作用。方法:建立肾阳虚遗尿大鼠模型,用遗尿方进行治疗,运用酶联免疫吸附技术测定大鼠血清AVP的含量。结果:模型组血清AVP浓度显著低于正常组(P<0.05),尿量明显增多,持续3周左右;治疗组血清AVP浓度较模型组升高,且在治疗结束时尿量及血清AVP浓度与正常组比较无明显差异。结论:遗尿方具有升高血清AVP浓度,减少尿量,治疗遗尿的作用。OBJECTIVE To study the changes of serum levels of AVP and the regulatory effects of Yiniao Fang in enuresis model rats. METHODS The enuresis rat model was established and treated with Yiniao Fang, the enzyme - linked immunosorbent assay was used to measure the serum levels of AVP in rats. RESULTS The level of serum AVP concentration in model group was significantly lower than that in control group （P〈0. 05）, and the urine volume in model group increased significantly, which continued to about 3 weeks. In the treatment group compared with the model group, the serum AVP concentration increased; and at the end of treatment, the urine volume and the serum AVP concentration which compared with normal group showed no significant difference. CONCLUSION Yiniao Fang can elevate serum AVP concentration, reducing urine output, it possesses anti-enuresis effect.

关 键 词：遗尿方 遗尿症 抗利尿激素 尿量 

分 类 号：R963[医药卫生—微生物与生化药学]