煤矿工人诱导痰中白细胞介素的检查及临床意义  

Clinical Significance of Detection of Interleukin in Induced Sputa of Coalminers

作　　者：万恩广[1] 张家鹏[2] 王瑞[3] 郭磊[1] 

机构地区：[1]兖矿集团有限公司劳动卫生职业病防治所,山东济宁273500 [2]兖矿集团有限公司兴隆庄煤矿医院,山东济宁272102 [3]山东省职业卫生与职业病防治研究院,山东济南250001

出　　处：《工业卫生与职业病》2010年第3期139-142,共4页Industrial Health and Occupational Diseases

摘　　要：目的探讨煤矿接尘工人诱导痰中白细胞介素-6(IL-6)、白细胞介素-16(IL-16)含量变化及临床意义。方法实验室测定接尘组110人、矽肺患者54人、对照组32人诱导痰中IL-6、IL-16含量,并对IL-6、IL-16与接尘工龄的相关性进行分析。结果 3组调查对象诱导痰中IL-6含量差异无统计学意义(P>0.05);接尘组和矽肺组诱导痰中IL-16含量明显高于对照组,差异有统计学意义(P<0.05或P<0.01),接尘组与矽肺组间IL-16含量差异无统计学意义(P>0.05);矽肺组和接尘组诱导痰中IL-6、IL-16水平与接尘工龄无相关性(r=0.0814,P>0.05;r=0.1690,P>0.05)。结论诱导痰中IL-16含量可以反映煤矿接尘工人的肺组织炎症反应。Objective To study the changes and significance of IL-6 and IL-16 in induced sputa of dust exposed coal miners. Methods Induced sputa of 110 dust exposed coal miners, 54 silicosis patients, and 32 unexposed workers as the control were collected, in which IL-6 and IL-16 were determined. Correlation between the contents of IL-6 and IL-16 and working age was analyzed. Results The differences in levels of IL-6 in induced sputa were not statistically significant in all three groups （P〉0.05）. The concentrations of IL-16 in induced sputa of patients group and dust exposed group were significantly higher than those of the control group （P〈0. 05 or P〈0. 01）. The IL-16 contents in patients group and dust exposed group were not statistically different （P〉0.05）. Levels of IL-6 and IL-16 in induced sputa of patients group and dust exposed group showed no correlation with the years of dust exposure （ r= 0. 0814, P 〉 0.05, r = 0. 1690, P〉 0. 05）. Conclusions The contents of IL-16 in induced sputa might reflect the inflammation reaction in lung tissues of dust exposed coal miners.

关 键 词：煤矿接尘工人 诱导痰 IL-6 IL-16 

分 类 号：R135.2[医药卫生—劳动卫生]