职业性氟接触人群氟性骨损伤致病风险关联分析  

Risk Correlation Analysis of Fluoride Induced Bone Injury among Occupational Fluoride Exposed Population

作　　者：刘克俭[1] 孙志浩 张裕曾[1] 南涤飞 涂俊[1] 万才珍[4] 王宝珊[5] 宋玉娥[1] 崔彩岩[1] 

机构地区：[1]华中科技大学同济医学院,湖北武汉430030 [2]汉江集团丹江铝业公司医院,湖北丹江442700 [3]黄岗白莲铝业集团公司医院,湖北黄冈438000 [4]武汉钢铁公司职业病防治研究所,湖北武汉430060 [5]华中科技大学附属梨园医院,湖北武汉430070

出　　处：《工业卫生与职业病》2010年第3期159-162,共4页Industrial Health and Occupational Diseases

基　　金：国家自然科学基金资助项目(30671742)

摘　　要：目的探讨职业性氟接触人群氟性骨损伤致病风险评价指标,通过风险评价,预测病情分布,分析致病因素,为风险控制策略的制定提供依据。方法通过归纳职业性氟接触人群氟性骨损伤的关联指标,描述与评价空气氟摄入量、日氟摄入量,以及尿氟、血氟与氟性骨损伤的关系,计算和获得特定剂量下评价职业性氟接触人群发生氟性骨损伤危险性的基准剂量(benchmark dose,BMD)及其95%的可信限下限值(benchmark dose lower-bound confidence limit,BMDL)。结果空气氟摄入量、日氟摄入量、以及尿氟、血氟与氟性骨损伤的发生率间具有明显的剂量-反应关系,r=0.995～0.998,BMD分别为3.22 mg/m3、4.08 mg/人.日、3.10 mg/L和0.23 mg/L,BMDL分别为2.86 mg/m3、3.61 mg/人.日、2.68 mg/L和0.20 mg/L,其计算的参考剂量(reference dose,RfD)分别为1.43 mg/m3、3.61 mg/人.日、2.68 mg/L和0.20 mg/L。结论职业性氟接触人群氟性骨损伤致病风险增高与空气氟摄入量、日氟摄入量、以及尿氟、血氟含量密切相关。建议采取降氟、机体排氟、改变生活方式、改善营养结构等措施进行预防,降低氟性骨损伤致病风险。Objective To explore risk evaluation indicators of fluoride induced bone injury among the occupational fluoride exposed population and to provide criteria for formulating risk control strategies. Methods For integrating the correlated indexes of fluoride induced bone injury among occupational fluoride exposed population, daily fluoride intake, urinary and blood fluoride and their correlation with bone injury were described and evaluated. A benchmark dose（BMD）value and the benchmark dose lower bound confidence limit（BMDL）for evaluating the risk of fluoride induced bone injury among fluoride exposed population were calculated and obtained. Results Correlation existed between the concentration of fluoride in the air of workplaces, fluoride daily intake, urinary and blood fluoride and fluoride induced bone injury showing a significant dose response relationship with r= 0. 995 -0. 998, BMD 3. 223 mg/m^3 and 4.08 mg/person daily, and 3. 10 mg/L and 0. 23 mg/L, and BMDL 2. 86 mg/m^3 , 3.61 mg/person daily, and 2. 68 mg/L and 0. 20 mg/L. Calculated reference doses were 1.43 mg/m^3 , 3. 61 mg/person daily, and 2. 68 mg/L and 0. 20 mg/L. Conclusions Close correlation exists in the risk of fluoride induced bone injury with the concentration of fluoride in the air of workplaces, daily fluoride intake and urinary and blood fluoride concentration among fluoride exposed population. It is suggested that measures to lower the fluoride concentration in the air of workplaces, to promote the excretion of fluoride, to change the life style, and to improve the nutrition components should be taken so as to prevent and reduce the risk of fluoride induced bone injury.

关 键 词：氟 氟性骨损伤 致病风险 关联分析 

分 类 号：R135[医药卫生—劳动卫生]