冻干水痘减毒活疫苗免疫效果观察  

Study on Epidemiological Effect of the Freeze-dried Live Attenuated Varicella Vaccine

作　　者：曹金梅 卢新玉[2] 

机构地区：[1]胶南市中医医院,山东266400 [2]胶南市疾病预防控制中心

出　　处：《医学动物防制》2010年第5期439-441,共3页Journal of Medical Pest Control

摘　　要：目的评价冻干水痘减毒活疫苗(Varicella Freeze-dried Attenuated Live Vaccine,VarV)的现场流行病学效果和疫苗安全性。方法选择未发生过水痘流行、无水痘患病史、未接种过VarV的小学生和托幼机构儿童作为观察对象,采取随机、盲法、对照的方法 ,将入选的观察对象分成试验组2588人,接种VarV;对照组2598人,接种流行性腮腺炎减毒活疫苗。结果经追踪随访,试验组发病率为2.70‰,对照组为14.63‰。结论具有良好的现场流行病学保护效果和安全性。Objective To evaluate the safety serological and epidemiological effect of the Freezedried Live attenuated varicella vaccine produced by Changchun Keygen.bioligical products co.Method A random control clinical trial was adopted.5186 noninfectded children who aged from 3～9 years old were divided randomly into exper-imental group （2588 children） and control group （2598 children）.Results In the observation period,the incidence of varicella was 2.70% in the experimental group and 14.63‰.Conclusions The varicella vaccine produced by Keygen was safe and effective.

关 键 词：冻干水痘减毒活疫苗 随机对照 疫苗效果 

分 类 号：R186[医药卫生—流行病学]