Exendin-4与神经退行性疾病的关系  

Relationship between exendin-4 and neurodegenerative diseases

作　　者：柳超[1] 郭军[1] 

机构地区：[1]南京医科大学基础医学实验教学中心,江苏南京210029

出　　处：《中国药理学通报》2010年第5期566-569,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No30871200);江苏省卫生厅自然科学基金资助项目(NoH200749)

摘　　要：Exendin-4是一种糖尿病新药,也是胰高血糖素样肽-1(GLP-1)类似物,能激活GLP-l受体,上调cAMP发挥生理活性。GLP-1受体与神经元可塑性及存活密切联系。Exendin-4还能激活多条信号通路,调节胞内钙离子(Ca2+)稳态,减轻兴奋性毒性,抑制细胞凋亡,促进神经元增生、分化,对神经退行性疾病有治疗作用。该文旨在阐明exendin-4的神经保护机制,为神经退行性疾病的预防与治疗提供新思路。Exendin-4,a peptide analogue of glucagon-like peptide-1（GLP-1）,is presently in clinical trials as a therapy for type 2 diabetes mellitus.Exendin-4 selectively acts on GLP-1 receptors,which are coupled to the cAMP nucleotide second messenger pathway to enhance the survival and plasticity of neurons in the brain.Exendin-4 has potent effects on homeostasis of Ca2＋,on multiple targets to block apoptotic signaling pathways,and on neuronal proliferation and differentiation.It has also been demonstrated to possess properties against oxidative stress and excitotoxicity.In this review the functions of exendin-4 on central nerve system and the potentia therapeutic effects on neurodegenerative diseases will be involved.

关 键 词：EXENDIN-4 GLP-1受体 CAMP 神经退行性疾病 

分 类 号：R341.6[医药卫生—基础医学] R742.2