TIM家族成员的免疫调控作用研究进展  

Role of TIM family members in immune regulation:recent progress

作　　者：肖亮[1] 董家勇[1] 刘芳[1] 王全兴[2] 丁国善[1] 傅志仁[1] 

机构地区：[1]第二军医大学长征医院肝移植科,上海200003 [2]第二军医大学基础部免疫学教研室,上海200433

出　　处：《第二军医大学学报》2010年第5期537-540,共4页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金面上项目(30772056)~~

摘　　要：T细胞免疫球蛋白黏蛋白(T-cell immunoglobulin and mucin,TIM)基因被发现表达于小鼠染色体11B1.1。TIM分子广泛存在于多种免疫细胞特别是抗原呈递细胞表面,可参与天然免疫和获得性免疫;某些TIM分子存在着多种配体,对T细胞具有双重作用;TIM的异常表达与多种疾病发生有关,可能作为药物治疗的新靶点;TIM与调节性T细胞(Tregs)相关性研究为移植免疫耐受诱导提供了新思路。因此,本文就TIM家族成员的免疫调节功能作一综述。TIM （T-cell immunoglobulin and mucin） gene,firstly found on mouse chromosome 11B1.1,is expressed by various kinds of immune cells,especially antigen presenting cells.TIM is involved in both innate immunity and adaptive immunity.Some TIM proteins can bind different ligands,exerting dual influence on T cells.The abnormal expression of TIM is associated with many kinds of diseases,making TIM a new target for pharmacotherapy.The relation of TIM and Tregs has cast new lights on transplantation immune tolerance.This paper focuses on the immune regulation function of TIM family.

关 键 词：T细胞免疫球蛋白粘蛋白 免疫调控 抗原呈递细胞 T淋巴细胞 

分 类 号：R392.11[医药卫生—免疫学]