益活清下法对重症急性胰腺炎患者血清单核趋化蛋白-1的影响  

Impact of Yihuo Qingxia Method on the Serum Monocyte Chemoattractant Protein-1 in Severe Acute Pancreatitis Patients

作　　者：金涛[1] 夏庆[1] 赵龙[1] 张海燕[1] 程征宇[1] 薛平[1] 杨晓楠[1] 

机构地区：[1]四川大学华西医院中西医结合科,四川成都610041

出　　处：《华西医学》2009年第10期2565-2568,共4页West China Medical Journal

基　　金：国家科技支撑计划项目(2006BAI04A15);四川省中医药管理局中西医结合急性胰腺炎防治中心建设项目及科研项目(2007B03)资助

摘　　要：目的:探讨益活清下法治疗重症急性胰腺炎(severe acute pancreatitis,SAP)对血清单核趋化蛋白-1及对器官功能不全的影响。方法:依据纳入和排除标准,选取SAP患者24例,按1:1随机分为治疗组和对照组,在接受相同西医治疗的基础上,治疗组使用中药"益活清下"法治疗,对照组同时接受中药安慰剂治疗。测定患者第0、1、3、5、7天血清MCP-1的浓度水平,比较各器官功能不全的发生率与持续时间。结果:两组入院时Rason评分、CT评分、急性生理和慢性健康评价指标Ⅱ评分无统计学差异(P>0.05)。对照组第3天MCP-1浓度水平明显高于治疗组,差异有统计学意义(P<0.05),对照组肠、肝功能不全的发生率高于治疗组,持续时间长于治疗组,但无统计学差异(P>0.05)。结论:益活清下法治疗重症急性胰腺炎,可降低患者血清MCP-1的水平。Objective：To investigated the impact of Yihuo Qingxia method on the serum monocyte chemoattractant protein-1 of severe acute pancreatitis （SAP）and on the organs disfunction.Methods：Twenty-four SAP patients who admitted to hospital within 72h after onset were randomized into treatment group （n=12） and control group （n=12）.The patients in the treatment group were treated by Yihuo Qingxia method,and the control group were administrated with placebo.The level of the serum mcp-1 of the patients on the first,3^rd,5^th,7^th day were measured,as well as the incidence and the duration of disfunction of the organs were compared.Results：There were no statistical significance in admission Rason scores,CT scores,Acute physiology and chronic health evaltionⅡscores（APACHEⅡscores）（P〉0.05）.The level of the serum Monocyte chemoattractant protein-1 of the treatment group was lower than that of the placebo group generally（P〈0.05）.At the 3^rd day after onset,the serum mcp-1 level of the control group was significantly higher than that of the treament group（P〈0.05）.The incidence of the control group of the intestin disfunction and hepatic inadequacy was obviously higher than those of the treatment group,and the duration of the former was longer than that of the latter,but with no satistical significance.Conclusion：Yihuo Qingxia method can effectively cut down the level of the serum mcp-1 of severe pancreatitis patients.

关 键 词：重症急性胰腺炎 益活清下法 单核趋化蛋白-1 

分 类 号：R259[医药卫生—中西医结合]