抗dsDNA抗体补体C3、C4和系统性红斑狼疮活动的相关性  

作　　者：范云燕[1] 余静[2] 

机构地区：[1]德阳市中西医结合医院内科,四川德阳618000 [2]德阳市人民医院风湿免疫科,四川德阳618000

出　　处：《医学信息（医药版）》2009年第4期33-35,共3页

摘　　要：目的：探讨自身抗体中抗dsDNA抗体及补体C3、C4与系统性红斑狼疮（SLE）患者狼疮活动相关的临床研究。方法：回顾性分析58例系统性红斑狼疮（SLE）患者的临床情况。对抗dsDNA抗体及补体C3、C4与SLE活动的关系进行了探讨与分析。结果：C3下降较C4下降对诊断SLE活动更具价值，dsDNA抗体升高，对SLE活动的判断很有价值。C3下降及dsDNA抗体升高，应对病情活动加以判断，当补体C3、C4均低而dsDNA抗体升高时对诊断SLE活动价值最大。结论：血清中ds—DNA抗体、补体与系统性红斑狼疮病情活动性高度相关。Objective To study the relativity between the level of complement, anti - dsDNA, and systemic lupus erythematosus activity. Methods analysed 58 patients with systemic lupus erythematosus（SLE） and discussed the relation between the level of anti-dsDNA, complement, and disease activity. Results Lower serum level of C3 was more valuable than that of C4 in SLE activety. Higher serum level of anti-dsDNA was valuable in SLE activity. Lower level of C3 and higher level of anti-dsDNA were used as a predictor of disease activity. Lower level of complement （C3, C4）and higher level of anti-dsDNA was the most valuable to activity in SLE. Conclusion The level of complement and anti-dsDNA were associated with systemic lupus erytbematosus activity.

关 键 词：系统性红斑狼疮 抗DSDNA抗体 补体 

分 类 号：R593.241[医药卫生—内科学]