黄花蒿提取液抗蒽环类化疗药物的心脏毒性作用  

Protection of Artemisia Annua Extracts Against Cardiac Toxicity of Marcellomycin in Chemotherapy

作　　者：寇晓梅[1] 张晨芳[1] 李芬[1] 李燕[1] 柯永莉[1] 

机构地区：[1]广州军区广州总医院普通外科,广东广州510010

出　　处：《广州医学院学报》2009年第6期28-30,共3页Academic Journal of Guangzhou Medical College

摘　　要：目的:在乳腺癌患者中,观察黄花蒿提取液抗蒽环类药物化疗所致心脏毒性的作用。方法:从本院普外科的92例浸润性乳腺癌患者中,随机分为治疗组46例和对照组46例。治疗组在应用蒽环类药物化疗同时给予黄花蒿提取液口服,对照组单用化疗药物,观察两组患者在化疗过程中的心脏毒性反应和心功能的变化。结果:治疗组仅1例出现急性心脏毒性反应,发生率为2.17%,而对照组有6例,发生率为13.04%,明显高于治疗组(P<0.05)。两组治疗前LVEF无明显差异,化疗后对照组较治疗组下降29.9%,P<0.01。对照组的血清肌钙蛋白水平在各个时段均高于治疗组(P<0.05),并随着化疗时间的延长而逐渐增高。结论:黄花蒿提取液在蒽环类药物化疗过程中具有心脏保护作用,是较好的心肌细胞保护剂。Objective： To investigate the protection of Artemisia annua extracts against cardiac toxicity of marcellomycin in patients with breast cancers. Methods：92 patients were randomized into the control group to receive marccllomycin alone or the treatment group to receive marcellomycin plus Artemisia annua extracts. The cardiac toxicity and functions were compared during chemotherapy between the two groups. Results： 1 （2.17%） case in the treatment group and 6 （13.04%） in the control group showed acute cardiac toxic reaction （P 〈 0.05 ）. While the two groups had comparable LVEF before treatment, the control group showed 29.9% lower LVEF as compared with treatment group after marcellomycin use. The levels of troponin increased more in the control group than did in the treatment group, and also appeared higher along with time. Conclusion：Artemisia annua extracts may be reliable as a cardioprotective agent during chemotherapy with marcellomyein.

关 键 词：黄花蒿提取液 蒽环类药物 化疗 心脏保护 

分 类 号：R453[医药卫生—治疗学]