天然药物青蒿素及其衍生物的作用机理研究进展  

Advances of Pharmacological Action Research of Natural Medicine Artemisinin and Its Derivatives

作　　者：丁焕新[1,2] 李镜锋[1,2] 陈旭明[1,2] 李立[1,2] 

机构地区：[1]昆明市第一人民医院 [2]昆明医学院附属甘美医院肝胆胰腺外二科,昆明650011

出　　处：《中国普外基础与临床杂志》2010年第5期519-521,共3页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的探讨天然药物青蒿素及其衍生物的药理作用及机理。方法复习近年来国内、外相关文献并进行综述。结果青蒿素及其衍生物结构独特、高效低毒,除具有抗疟疾作用外,亦被证明具有抗肿瘤、调节免疫功能、抗菌、抗孕、抗纤维化、清热解毒等药理作用。结论青蒿素及其衍生物通过不同的途径发挥药理作用,具有较好的应用前景。Objective To investigate the pharmacological effects and mechanisms of natural medicine artemisinin and its derivatives.Methods The pertinent domestic and overseas literatures of recent years were reviewed and summarized.Results Artemisinin and its derivatives have unique structure,high efficiency with low toxicity.The pharmacological effects include anti-malaria,anti-tumor,immune function regulation,anti-bacterial,anti-fetation,anti-fibrosis,heat-clearing and detoxicating,etc.Conclusion Artemisinin and its derivatives play pharmacological effects in different ways,and have a good foreground in the application.

关 键 词：青蒿素 青蒿素类衍生物 药理作用 抗肿瘤 免疫机理 

分 类 号：R284.1[医药卫生—中药学] R285[医药卫生—中医学]