基因药物呼吸道给药载体的发展  

Development of vectors used in pulmonary gene delivery

作　　者：储辰[1] 徐宇虹[1] 

机构地区：[1]上海交通大学药学院,上海200240

出　　处：《上海交通大学学报（医学版）》2010年第5期592-596,共5页Journal of Shanghai Jiao tong University:Medical Science

基　　金：国家自然科学基金(30801446)~~

摘　　要：基因药物的呼吸道给药是基因治疗的主要途径之一。基因药物呼吸道给药系统由基因药物、基因载体和吸入装置组成。基因载体具有保护基因药物以及协助基因药物发挥作用等功能,分为病毒载体和非病毒载体两类。病毒载体由于不良反应较重,使用不广泛。阳离子脂质是最早用于基因药物呼吸道给药的非病毒载体,后被阳离子聚合物取代。聚乙烯亚胺是目前研究最多的阳离子聚合物载体,有良好的介导基因药物给药能力。新一代阳离子聚合物载体聚酯胺具有广阔的应用前景。Pulmonary gene delivery is one of the main branches of gene therapy.Pulmonary gene delivery system consists of gene drugs,vectors and pulmonary delivery devices.Vectors,which can protect gene drugs and mediate gene delivery,are divided into viral vectors and non-viral vectors.Viral vectors have greater toxicity,and are less widely used.Cationic lipids served as non-viral vectors of first generation,and were later replaced by cationic polymers.Polyethylenimine vectors,which have favourable gene transfection efficiencies,are most widely studied.New cationic polymer poly ester amine vectors enjoy broad application prospects in pulmonary gene delivery.

关 键 词：基因药物 载体 吸入装置 呼吸道给药 

分 类 号：R945[医药卫生—微生物与生化药学]