运动对骨骼肌丝裂原活化蛋白激酶信号系统的影响  

Effects of exercise on mitogen-activated protein kinases signaling pathway in skeletal muscle

作　　者：洪熊[1] 张玮[2] 

机构地区：[1]江西师范大学体育学院,江西省南昌市330027 [2]江西中医学院体育教学部,江西省南昌市330004

出　　处：《中国组织工程研究与临床康复》2010年第20期3748-3752,共5页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：背景:丝裂原活化蛋白激酶是生物体内重要的信号转导系统之一,参与介导生长、发育、分裂、分化、死亡以及细胞间的功能同步等多种细胞过程。目的:总结丝裂原活化蛋白激酶对运动后骨骼肌适应性变化的重要作用。方法:采用计算机检索中国期刊全文数据及PubMed数据库1990-01/2009-06期间的相关文章,检索词为"运动;丝裂原活化蛋白激酶信号系统;骨骼肌;适应,Exercise;Mitogen-activated protein kinases; skeletal muscle;adaption"。纳入与运动和丝裂原活化蛋白激酶信号系统研究现状与发展密切相关的文章,排除重复性研究。结果与结论:运动能够激活骨骼肌中丝裂原活化蛋白激酶信号传导系统,不同运动方式、不同类型的肌肉以及训练的时间长短都可以影响到丝裂原活化蛋白激酶的激活,而且激活后丝裂原活化蛋白激酶具有不同的时相性,丝裂原活化蛋白激酶对运动后骨骼肌的适应性变化具有重要作用。通过研究探索丝裂原活化蛋白激酶对运动后骨骼肌的适应性变化,有利于以运动相关的丝裂原活化蛋白激酶为靶点,研制和开发运动功能性食品或抗疲劳药物。BACKGROUND： Mitogen-activatedprotein kinases （MAPKs） are serine/threonine-specific protein kinases that respond to extracellular stimuli and regulate various cellular activities, such as gene expression, mitosis, differentiation, proliferation, and cell survival/apoptosis. OBJECTIVE： To summarize the important effects of MAPKs on postexercise skeletal muscle. METHODS： The Chinese Full Text Databases （website： http：//dlib.cnki.net/kns50/index.aspx） and PubMed （website： http：//www. ncbi.nlm.nih.gov/pubmed/） were retrieved by computer from 1990-01 to 2009-06 with Keywords of ＂exercise, mitogen-activated protein kinases, skeletal muscle and adaption＂. The papers concerning research status and development trend of exercise on MAPK were included, and the repeated research was excluded. RESULTS AND CONCLUSION： Exercise can activate MAPK signal transduction system of skeletal muscle, and different types of exercises, skeletal and training times had varying effects on MAPKs. MAPKs are involved in skeletal muscle adaption and exhibited different time courses after exercise. The study of adaptability changes of MAPKs on postexercise skeletal muscle is conductive to prepare and develop motor function foods or antifatigue drugs.

关 键 词：运动 丝裂原活化蛋白激酶信号系统 骨骼肌 适应 肌肉肌腱组织工程 综述文献 

分 类 号：R318[医药卫生—生物医学工程]