维汉两民族原发性高血压伴颈动脉粥样病变与对氧磷酶2基因多态性的相关性:同一机构3年430例报告  

Association between primary hypertension accompanying carotid atherosclerosis and paraoxonase 2 polymorphisms in Uighur and Han populations: A 3-year report of 430 cases in the same institute

作　　者：赵芳[1] 徐新娟[1] 马岩萍[2] 任容[3] 马杰[1] 梁晓慧[1] 

机构地区：[1]新疆医科大学附属第一医院高血压科,新疆维吾尔自治区乌鲁木齐市830054 [2]乌鲁木齐武警新疆总队医院高血压科,新疆维吾尔自治区乌鲁木齐市830054 [3]新疆医科大学附属第五医院肾病科,新疆维吾尔自治区乌鲁木齐市830054

出　　处：《中国组织工程研究与临床康复》2010年第20期3762-3767,共6页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：乌鲁木齐市科学技术项目(Y05331001)~~

摘　　要：背景:近年的研究发现对氧磷酶2(PON2)可降低低密度脂蛋白的过度氧化从而保护组织免受氧化破坏。目的:分析对氧磷酶2基因多态性(PON2C311S)与原发性高血压伴颈动脉粥样病变的关系。方法:选择2006-01/2009-01新疆医科大学附属第一医院收治的高血压患者共430例,其中294例伴颈动脉粥样病变者为病变组,136例颈动脉内膜正常者为对照组。病变组中汉族214例,维族80例;对照组中汉族103例,维族33例。采用多聚酶链反应-限制性内切酶片断长度多态性技术分析对氧磷酶2基因多态性基因多态性。结果与结论:汉族病变组的CC+CS基因型及C等位基因频率明显高于对照组;舒张压在对氧磷酶2基因多态性位点3种基因型(SS、CS、CC)之间差异有显著性意义(P=0.003),CC基因型舒张压最高。Logistic回归分析表明PON2C311等位基因、年龄、舒张压、脂蛋白(a)是高血压伴发颈动脉粥样病变的危险因素(P<0.05)。维族病变组的CC+CS基因型及C等位基因频率高于对照组;低密度脂蛋白胆固醇在对氧磷酶2基因多态性位点3种基因型之间差异有显著性意义(P=0.005),CC基因型低密度脂蛋白胆固醇最高。结果提示,新疆地区汉族高血压人群对氧磷酶2基因多态性基因多态性与颈动脉粥样病变有关,C等位基因是高血压伴发颈动脉粥样病变的危险因素之一。BACKGROUND： Recently studies demonstrated that paraoxonase-2 （PON2） can decrease low density lipoprotein overoxidation and protect tissues against oxidation damage. OBJECTIVE： To investigate the relationship between PON2 polymorphisms （PON2 C311S） and primary hypertension accompanying carotid atherosclerosis. METHODS： The study comprised 430 participants who admitted at the First Affiliated Hospital of Xinjiang Medical University were collected and divided into 2 groups： primary hypertension accompanying carotid atherosclerosis （n=294） and primary hypertension without carotid atherosclerosis （n=136）. The case group was consisted of 214 Han people and 80 Uighur people. The control group consisted of 103 Han people and 33 Uighur people. Genotypes were detected by polymerase chain reactions followed by restriction analyses with specific endonucleases and their frequencies were determined. RESULTS AND CONCLUSION： The CC＋CS genetype distribution and the C allele frequency of the PON2 C311S gene were obviously increased in the Han case group than that of the control group. Diastolic blood pressure of Han people with three genetypes （SS, CS, CC） exhibited a significant difference （P=0.003）, especially greatest in the CC genetype. Logistic regression analysis demonstrated that allele of PON2 C311, age, diastolic blood pressure, lipoprotein （a） were the risk factors of hypertension accompanying carotid atherosclerosis （P 0.05）. The genetype and C allele frequency of PON2 C311S gene was greater in the Uighur case group than that of the control group, and the low density lipoprotein exhibited a significant differences in Uighur people with three genetypes （P=0.005）, especially highest in the CC genotype. The single nucleotide polymorphism of PON2C311S is probably associated with carotid atherosclerosis in primary hypertension people of Chinese Han population in Xinjiang. The C allele might be a risk factor.

关 键 词：对氧磷酶 基因多态性 原发性高血压 颈动脉粥样病变 维吾尔族 汉族 

分 类 号：R318[医药卫生—生物医学工程]