妊娠肝内胆汁淤积症与脐血神经元特异性烯醇化酶的关系  

Relationship between intrahepatic cholestasis of pregnancy and the umbilical cord blood neuron-specific enolase

作　　者：石玉龙[1] 孙迎春[1] 

机构地区：[1]铜陵市人民医院儿科,安徽铜陵244000

出　　处：《海南医学》2010年第11期22-23,共2页Hainan Medical Journal

摘　　要：目的探讨不同程度的妊娠期肝内胆汁淤积症(ICP)对新生儿中枢神经系统的损伤。方法将76例ICP患者按血清胆汁酸(TBA)水平分为三组,分别观察其羊水污染情况,并留取脐静脉血检测神经元特异性烯醇化酶(NSE)浓度,同时选取因社会因素选择剖宫产的21例作为对照组,同样方法留取脐静脉血检测NSE浓度。结果三组ICP的羊水污染率与血清TBA水平呈正相关,差异具有统计学意义,轻度ICP组NSE无明显升高,与对照组相比,差异无统计学意义,中、重度组与对照组相比差异显著,且中、重度组间相比,差异具有统计学意义。结论虽然ICP产妇预后良好,但不良妊娠结局明显增加,且中、重度ICP对婴儿中枢神经损伤较为明显,需对婴儿进行早期干预,以期尽量减少后遗症的发生率。Objective To explore the damage of varying degrees of intrahepatic cholestasis of pregnancy to neonatal central nervous system.Methods 76 ICP sufferers were divided into three groups according to serum total bile acid levels.Observe the conditions of amniotic fluid contamination and collect cord blood to detect the concentration of neuron-specific enolase.At the same time,select 21 cases of cesarean section due to social factors as a control group,collecting cord blood to detect the concentration of NSE in the same way.Results The rate of amniotic fluid contamination of three groups has a positive correlation with the level of serum TBA with a statistically significant difference.The NSE of the mild cases did not increase obviously,therefore there was no statistically significant difference comparing with the control group.Both of the moderate group and the severe group had significant differences with the control group.It also has a significant difference between the two groups.Conclusion Though the prognosis of the puerperas suffered CIP is good,it has a marked increase in adverse pregnancy.The moderate and severe cases of CIP have an obvious damage to the infants＇ central nervous system.It is necessary to carry on early intervention in infants to reduce the incidence of sequelae.

关 键 词：妊娠期肝内胆汁淤积症 羊水污染 脐带血 神经元特异性烯醇化酶 

分 类 号：R714.25[医药卫生—妇产科学]