长期接受高效抗逆转录病毒治疗的不良反应研究进展  

Long-term adverse reactions of highly active antiretroviral therapy

作　　者：赵柯[1] 孙永涛[1] 

机构地区：[1]第四军医大学唐都医院传染科,西安710038

出　　处：《世界临床药物》2010年第6期343-347,共5页World Clinical Drug

摘　　要：高效抗逆转录病毒治疗(HAART)已大大提高了获得性免疫缺陷综合征(AIDS)患者的生存年限。人们在设法降低药物成本、增强药物疗效的同时,越来越关注抗逆转录病毒药物的不良反应。后者临床表现多样,短期用药可出现胃肠道症状、过敏反应、药物性肝损害、骨髓抑制及乳酸酸中毒等,长期用药不良反应有脂肪重新分布、胰岛素抵抗、血脂异常及心血管疾病等。本文主要概述长期接受HAART者的不良反应及其发生机制。Highly active antiretroviral therapy（HAART） has resulted in a substantial improvement of life-span for patients with acquired immune deficiency syndrome（AIDS）.More and more attention is focused on the adverse reactions of antiretroviral drugs while increasing efforts are put into decreasing the antiviral cost and enhancing its efficacy.The adverse reactions may be transient,such as gastrointestinal reactions,allergy,drug-induced hepatic damage,marrow suppression and lactic acidosis.Whereas some adverse reactions could reveal only after long-term exposure to HAART medication,including fat redistribution,insulin resistance,dyslipidemia and cardiovascular disease.In this review,we discuss long-term adverse reactions of HAART and its possible pathogenesis.

关 键 词：抗逆转录病毒治疗 长期 脂肪重新分布 胰岛素抵抗 血脂异常 心血管疾病 

分 类 号：R978.7[医药卫生—药品]