低剂量纳洛酮对舒芬太尼镇痛效应的影响  

Effect of low-dose naloxone on analgesia of sufentanil

作　　者：张一肖[1] 何珂[2] 陶伟荣[1] 司振强[1] 严涛[1] 张科学[1] 黄辉[3] 徐姗姗[3] 戴体俊[4] 

机构地区：[1]徐州医学院麻醉学院,徐州221002 [2]徐州医学院临床医学一系,徐州221002 [3]徐州医学院公共卫生学院,徐州221002 [4]徐州医学院麻醉药理学教研室,徐州221002

出　　处：《世界临床药物》2010年第6期348-350,共3页World Clinical Drug

基　　金：国家自然科学基金资助项目(30471657;39970715);江苏省自然科学基金资助项目(BK200143);2007年江苏省高等学校大学生实践创新训练计划项目(396;404)

摘　　要：目的观察低剂量纳洛酮对舒芬太尼镇痛效应的影响。方法试验小鼠80只分为热板法试验组(n=40,均为雌性)和扭体法试验组(n=40,雌雄各半),各组再按分层随机区组设计分为SS组(舒芬太尼与生理盐水合用组)、SN1组、SN2组和SN3组(舒芬太尼分别与低剂量纳洛酮100、10和1ng/kg合用组),观察低剂量纳洛酮与舒芬太尼合用对小鼠热板法痛阈(HPPT)和扭体次数的影响。结果与SS组相比,SN3组HTTP值于用药后5和10min增高(P<0.05),小鼠扭体次数减少(P<0.05)。结论低剂量纳洛酮可增强舒芬太尼的镇痛效应,且以纳洛酮1ng/kg效果最好。Objective To observe the effect of low-dose naloxone on analgesia of sufentanil.Methods Eighty Kunming Jimpy mice were divided into 2 groups and treated by hot-plate method（n=40） and stretching method（n=40）respectively.Both groups were randomly divided into group SS（sufentanil combined with sodium chloride）,group SN1,group SN2 and group SN3（sufentanil combined with naloxone 100,10 and 1 ng/kg respectively）.Pain threshold in hot-plate test（HPPT） and the number of stretching times were observed.Results Compared with group SS,HPPT at 5 and 10 min in group SN3 increased significantly（P〈0.05）,and the number of stretching times in group SN3 reduced significantly（P〈0.05）.Conclusion Low-dose naloxone can enhance the analgesic effect of sufentanil in mice and its optimal dose could be 1 ng/kg.

关 键 词：纳洛酮 舒芬太尼 镇痛 联合用药 

分 类 号：R971-2[医药卫生—药品]