降钙素原用于新生儿感染诊断的临床价值  

Evaluation of procalcitonin on infection diagnosis for neonates

作　　者：崔赛男[1] 谷丽[1] 

机构地区：[1]同济大学附属第十人民医院儿科,上海200072

出　　处：《世界临床药物》2010年第6期351-354,共4页World Clinical Drug

摘　　要：目的探讨降钙素原(PCT)用于新生儿感染诊断的临床价值。方法 82例住院新生儿分为败血症组(n=21)、局部感染组(n=25)和非感染组(n=36),比较3组新生儿PCT、C-反应蛋白(CRP)和白细胞计数(WBC)水平,分析其阳性率以及用于新生儿败血症诊断的敏感度、特异度、阳性预测值、阴性预测值和准确度。结果败血症组、局部感染组及非感染组PCT阳性率分别为90.48%、56.00%及8.33%;与非感染组相比,败血症组和局部感染组差异显著,且败血症组和局部感染组相比也有显著差异(P<0.001),提示感染的严重程度与血清PCT水平呈正相关。以2ng/mL为临界值,PCT诊断新生儿败血症的敏感度为71.43%,特异度为98.36%,明显高于CRP的敏感度和特异度。结论 PCT对新生儿感染的早期诊断具有较高的敏感度和特异度,与CRP相比,对新生儿败血症等重症感染的诊断优势明显。Objective To evaluate procalcitonin（PCT） on infection diagnosis for neonates.Methods Eightytwo hospitalized neonates were divided into septicemia group（n=21）,local infection group（n=25）and non-infection group（n=36）,and to compare their PCT,c-reactive protein（CRP） level and white blood cell（WBC） count and then to analyze these positive rates of PCT,CRP and WBC and their sensitivity,specificity,positive predict value（PPV）,negative predict value（NPV） as well as accuracy which used to diagnose neonatal septicemia in three groups.Results The positive rates of PCT in septicemia group,local infection group and non-infection group were 90.48%,56.00% and 8.33% respectively,and the differences between septicemia group and non-infection group,local infection group and non-infection group,as well as septicemia group and local infection group were significant（P〈0.001）.There was a positive correlation between the severity of infection and serum level of PCT.If 2.0 ng/mL was taken as the critical value,the sensitivity and specificity of PCT for the diagnosis of septicemia were 71.43% and 98.36% respectively,which were much higher than that of CRP.Conclusion PCT have a higher sensitivity and specificity for early infection diagnosis of neonates.Compared with CRP,PCT is of more advantage.

关 键 词：新生儿 感染 降钙素原 C反应蛋白 

分 类 号：R722.13[医药卫生—儿科]