血浆置换联合大黄灌肠对重型乙型肝炎HBV DNA水平的影响及意义  

Effects and significance of plasma exchange combined with rhubarb enema therapy on level of HBV DNA in patients with severe hepatitis B

作　　者：覃雪英[1] 陆启峰[1] 覃后继[1] 黄美金[1] 丘海先[1] 陆春雷[1] 

机构地区：[1]右江民族医学院附属医院,广西百色533000

出　　处：《现代中西医结合杂志》2010年第18期2211-2213,共3页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：右江民族医学院科研资助项目(0802005)

摘　　要：目的观察血浆置换联合大黄灌肠治疗后重型乙型病毒性肝炎患者HBV DNA水平变化及对预后的影响。方法用血浆置换联合大黄灌肠治疗36例重型乙型病毒性肝炎患者2周(C组),观察其治疗前后HBV DNA水平变化,并与常规内科治疗(A组)及常规血浆置换疗法(B组)比较。结果治疗后B组与C组HBV DNA水平显著下降(P均<0.01),C组下降幅度优于B组(P<0.01),A组无显著性变化(P>0.05),C组总有效率与A组及B组比较均有显著性差异(P均<0.01)。结论血浆置换联合大黄灌肠能有效降低重型乙型病毒性肝炎HBV DNA水平,改善患者预后。Objective It is to observe the change of level of HBV DNA in patients with severe hepatitis after plasma exchange combined with rhubarb enema therapy and the influence on prognosis.Methods 36 patients with severe hepatitis B were combin treated with plasma exchange and rhubarb enema therapy for 2 weeks（group C）,then the change of level of HBV DNA was observed after treatment,and compare with common medical treatment（group A） and common plasma exchange treatment（group B）.Results The levels of HBV DNA of group B and C both were decreased after treatment（P〈0.01）,and the extent of decrease in group C was bigger than that in group B（P〈0.01）.There was no statistical difference in group A after treatment（P〉0.05）.Comparing with group A and B,there was significance difference on total effective rate of group C（P〈0.01）.Conclusion It can effectively decrease the level of HBV DNA in patients with severe hepatitis by combined treatment with plasma exchange and rhubarb enema therapy,and can improve the prognosis for the patients.

关 键 词：重型乙型肝炎 大黄 血浆置换 HBV DNA 

分 类 号：R512.62[医药卫生—内科学]