慢性肝炎高压氧治疗前后肝血流及超微结构变化和疗效观察  

Alteration of hepatic blood flow and ultrastructure of hepatic tissue in chronic hepatitis after hyperbaric oxygenation and its effect

作　　者：赵伟[1,2] 陈锦飞[1,2] 张林[1,2] 陈宏 刘伟[1,2] 薜迪[1,2] 广庄华[1,2] 郑抗美[1,2] 孙溪滨 

机构地区：[1]南京市第二医院 [2]南京市鼓楼医院

出　　处：《中华理疗杂志》1999年第1期13-15,共3页Chinese Journal of Physical Therapy

基　　金：南京市科学技术委员会资助

摘　　要：目的：研究高压氧治疗慢性瘀胆型肝炎患者肝血流及肝脏病理超微结构的变化和疗效。方法：采用肝血流图仪及多普勒Ｂ超测肝血流图收缩波、门静脉右支的血流量与生化，免疫组化及治疗前后病理电镜检查数据为观察指标。结果：高压氧治疗后，７６％的患者肝血流图收缩波升高，７０％患者门静脉右支血流量增加，前后比较Ｐ＜０．０５。肝功能ＡＬＴ、ＢＩＬＩ好转率分别为８８．９％，９３．３％。线粒体肿胀、肝细胞及毛细胆管瘀胆明显减轻，Ｋｕｐｆｅｒ细胞减少，治疗前后比较Ｐ＜０．０５。结论：高压氧可明显增加门静脉、肝动脉血流量，改善肝功能。Objective:To stndy the effect and alteration of hepatic blood flow as well as ultrastructure of hepatic tissue in chronic cholestatic hepatitis after hyperbaric oxygenation(HBO).Methods: Using the hepatic rheometer and Doppler B-mode ultrasound equipment,the contractive wave of hepatic blood-flow graph and blood flow of portal vein were tested;the biochemistry,immunohistochemistry and ultrastructure of hepatic tissue were determined and as the evaluated indexes.Results:After the HBO treatment,the contractive wave of hepatic blood-flow graph in 76% patients and blood flow of right portal vein in 70% patients were increased;the improvement of ALT and BILI in hepatic function was 88.9% and 93. 3% respectively.In addition,the swollen mitochondria,cholestasis of hepatic cells and capillaries reduced obviously;Kupffer's cells decreased.There was significant difference(P<0.05) before and after HBO treatment.Conclusion:It is suggested that the HBO could increase the blood flow of portal vein and hepatic arteries,improve the hapatic function,cholestatsis and inflammation.

关 键 词：肝炎 超微结构 高压氧治疗 肝血流 

分 类 号：R512.605[医药卫生—内科学] R459.6[医药卫生—临床医学]