42.2GHz毫米波辐射孕鼠对子代的影响  

Effect of millimeter wave irradiation with 42.2GHz on the posterities of pregnant mice

作　　者：赵志刚[1] 吴芬芳[1] 薛金河 李国华 

机构地区：[1]解放军第二一O医院肿瘤科

出　　处：《中华理疗杂志》1999年第1期32-35,共4页Chinese Journal of Physical Therapy

基　　金：国家自然科学基金;辽宁省科学技术基金及全军医药卫生科研基金

摘　　要：目的：阐明４２．２ＧＨｚ毫米波对胚胎产生损伤效应阈值及导致成年子鼠学习记忆功能降低的机制，验证毫米波的生物效应有无频率特异性。方法：采用频率４２．２ＧＨｚ、功率密度１，３，５，８ｍＷ／ｃｍ２的毫米波，在小鼠怀孕６～１５天进行２ｈ／ｄ辐射，用Ｙ型电迷宫对成年子鼠进行学习记忆功能测试，分别用ＲＢＡ、ＨＰＬＣ－ＥＣＤ、ＲＩＡ法对足孕胚胎和成年子鼠脑Ｍ－Ｒ、单胺递质和ＡＶＰ进行测定。结果：≥５ｍＷ／ｃｍ２的毫米波导致成年子鼠学习记忆功能明显降低，成年子鼠垂体中ＡＶＰ含量明显降低，成年子鼠海马区Ｂｍａｘ明显升高，成年子鼠脑中ＤＯＰＡＣ、ＤＡ含量及足孕胚胎脑中ＤＡ含量明显降低，以上指标与功率密度及学习记忆成绩呈明显相关。结论：４２．２ＧＨｚ毫米波辐射导致胚胎损伤的阈值在３～５ｍＷ／ｃｍ２，导致成年子鼠学习记忆功能降低与使子鼠脑中ＡＶＰ、ＤＡ含量下降及海马区胆碱能神经活性降低相关，未见毫米波频率特异性效应。Objective:To determine the threshold of fetuses damaged by millimeter wave irradiation with 42.2GHz, to clarify the mechanism of lowering learning capacity and memory of offsprings of adult mice and to verify whether the millimeter wave has the effect of frequency-specific.Methods:Two-month old BALB/c mice were separately irradiated with 42.2GHz millimeter wave at power density of 1,3,5,8mW/cm 2 for 2h/per day from the 6th to 15th day of gestation.The learning capacity and memory of adult offsprings was determined on Y-type electric maze.The content of M-R,monoamine transmitter and AVP in brain of fetuses at term,adult offsprings was measured by RBA,HPLC-ECD and RIA method respectively.Results:It showed that using millimeter wave irradiation at ≥5mW/cm 2 ,the learning capacity and memory,the AVP,DOPAC and DA in brain of adult offsprings or fetuses at term were obviously lowered,but the quantity of M-R in adult offsprings was markedly increased. There was a significant correlationship among the above parameters,power density and learning capacity and memory.Conclusion:It is showed that the 42.2GHz millimeter wave irradiation at 3- 5mW/cm 2 may result in the threshold of fetus damage.The mechanism of lowering the learning capacity and memory of the adult offsprings is closely related to decrease of AVP,DA and reduction of function of cholinergic nerves in brain.There isn't the effect of frequency-specific.

关 键 词：毫米波 胚胎 辐射 子代影响 

分 类 号：R454.1[医药卫生—治疗学] R363.12[医药卫生—临床医学]