丹参酮ⅡA磺酸钠对心肌纤维化及Th_1/Th_2类细胞因子水平的影响  

Effects of Sodium Tanshinone ⅡA Sulfonate on Cardiac Fibrosis and Th_1/Th_2 Cytokines Levels

作　　者：杨乐[1] 王照华[1] 李树生[1] 杨光田[1] 赵立波[2] 

机构地区：[1]华中科技大学同济医学院附属同济医院急诊内科,武汉430030 [2]华中科技大学同济医学院药理学系,武汉430030

出　　处：《医药导报》2010年第6期701-703,共3页Herald of Medicine

摘　　要：目的观察丹参酮ⅡA磺酸钠(sodium tanshinone IIA sulfonate,STS)对老年小鼠高血压心肌纤维化及辅助性T细胞(Th)亚群Th1/Th2类因子水平的影响。方法老年小鼠行腹主动脉结扎构建高血压心肌纤维化模型,以STS腹腔注射进行干预。观察STS对心肌纤维化指标以及Th1/Th2类因子水平的影响。结果模型组心肌间质可见明显胶原沉积,STS处理组心肌纤维化程度明显减轻,外周血Th1类因子[白细胞介素(IL)-12、干扰素(IFN)-γ]水平下降,而Th2类因子(IL-4、IL-5)水平增加;STS处理组较模型组心肌I型胶原表达明显减少。结论 STS能调控老年小鼠高血压心肌纤维化,机制与调节Th1/Th2类因子水平有关。Objective To investigate effects of sodium tanshinone IIA sulfonate （STS） on hypertension-induced cardiac fibrosis and Th1/Th2 cytokines in aged mice. Methods Hypertension-induced cardiac fibrosis was established by abdominal aorta constriction in aged mice. Some mice were i.g. injected with STS,the control were injected with physiological saline. The cardiac fibrosis and Th1/Th2 cytokines were detected. Results The collagen fiber was deposited obviously in the cardiac interstitium of the model mice,but less could be seen in STS-treated group. In STS-treated group,Th1 cytokines （IL-12,IFN-γ） were decreased and Th2 cytokines （IL-4,5） were increased. The type I collagen expression in STS-treated group was less than the model. Conclusion STS can modulate hypertension-induced cardiac fibrosis in aged mice and the mechanisms may be related to regulation of Th1/Th2 cytokines levels.

关 键 词：丹参酮ⅡA磺酸钠 心肌纤维化 Th1/Th2类因子 

分 类 号：R282.71[医药卫生—中药学] R285.5[医药卫生—中医学]