氟比洛芬酯脂微球注射液对子宫全切术中应激反应的影响  

Effect of Flurbiprofen axetil lipid microsphere injection on stress during hysterectomy

作　　者：匡佳伟[1] 吴多志[1] 

机构地区：[1]海南省人民医院麻醉科,海南海口570311

出　　处：《海南医学院学报》2010年第5期623-625,共3页Journal of Hainan Medical University

基　　金：海南医学院科研基金资助学报项目(0020100173)~~

摘　　要：目的：观察氟比洛芬酯脂微球注射液对子宫全切术中机体应激反应的影响。方法：选择拟行全麻下腹式子宫全切术患者40例,ASA分级1~2级,随机分为观察组（F组）和对照组（C组）,每组各20例。两组均采用相同的麻醉诱导和维持方案,观察组于手术开始前10 min缓慢静注氟比洛芬酯脂微球注射液1 mg/Kg。记录麻醉前（T0）、切皮时（T1）、术毕（T2）和术后24 h（T3）的平均动脉压（MAP）和心率（HR）,并分别抽取肘静脉血2 mL,检测血浆皮质醇（Cor）和白细胞介素6（IL-6）含量,记录术中麻醉药物用量。结果：两组患者MAP、HR在T1-T3时与T0时比较均没有明显升高（P〉0.05）,F组低于C组但差异无统计学意义（P〉0.05）;F组Cor、IL-6含量在T1-T3时与T0时比较没有明显升高（P〉0.05）,而C组明显升高（P〈0.05）,两组比较差异有统计学意义（P〈0.05）;两组麻醉药物用量差异无统计学意义（P〉0.05）。结论：氟比洛芬酯脂微球注射液能降低腹式子宫全切术中机体的应激反应。Objective： To observe the effect of flurbiprofen axetil lipid microsphere injection on stress during hysterectomy.Methods： Forty patients at ASA class 1 and 2 underwent hysterectomy were randomly and equally divided into study group（group F） and control group（group C）.With the same anesthesia way,patients in group F were injected with flurbiprofen axetil lipid microsphere slowly at 1mg/kg 10 minutes before operation.The mean artery pressure（MAP）,heart rate（HR）,plasma concentration of corticosteroid（Cor） and interleukin-6（IL-6） were detected before anaesthesia（T0）,at skin incision（T1）,at the end of operation（T2） and postoperative 24h（T3）.Results： The MAP and HR at T1 to T3 had no significant increase comparing with those at To in both groups,the MAP and HR in group F were lower than those in group C,while there was no significant difference（P〈0.05）.The plasma level of Cor and IL-6 at T1 to T3 in group F were lower than those at To.While in group C they had significantly rise（P〈0.05）,and there was significant difference between two groups（P〈0.05）.Besides,there was insignificant difference in the dosage of anesthetics（P〈0.05）.Conclusion： Flurbiprofen axetil lipid microsphere injection can depress the stress during the hysterectomy.

关 键 词：氟比洛芬酯 应激反应 皮质醇 白细胞介素6 

分 类 号：R614[医药卫生—麻醉学]