山西省某县艾滋病患者单纯疱疹病毒感染状况及其影响因素的研究  

Prevalence and correlates of herpes simplex virus infections among AIDS patient in a county of Shanxi province,China

作　　者：陈莉[1] 杨清海[2] 董少良[2] 卫军[3] 贾望谦[1] 曲淑霞[3] 乔晓春[4] 何纳[1] 

机构地区：[1]上海市复旦大学公共卫生学院流行病学教研室公共卫生安全教育部重点实验室,200032 [2]山西省闻喜县疾病预防控制中心 [3]山西省运城市疾病预防控制中心 [4]山西省疾病预防控制中心

出　　处：《中华预防医学杂志》2010年第6期526-530,共5页Chinese Journal of Preventive Medicine

基　　金：基金项目：国家自然科学基金（30671880）;上海市教委科研创新项目（08ZZ02）;上海市重点学科建设项目（B118）

摘　　要：目的 了解山西省某县艾滋病患者中Ⅰ型和Ⅱ型单纯疱疹病毒（HSV-1,HSV-2）的感染率,并分别分析其影响因素.方法 对山西某县全部已纳入抗病毒治疗的195例艾滋病患者进行问卷调查.同时血清学检测确定其HSV-1和HSV-2的感染情况;利用单因素logistic回归模型分析数据.结果 共收回有效问卷195份,采集血样195份.195例艾滋病患者中,绝大多数（96.9%）为农民;男性116例（59.5%）,女性79例（40.5%）;年龄以20～50岁为主（146例,占74.9%）;已婚有配偶者180例（92.3%）.经有偿采供血或输血途径感染者176例,占90.3%.CD4＋：T细胞计数（1～1531）×106个/L[（323.6±14.8）×106个/L],26.5%患者的血液CD4＋T细胞计数〈200×106个/L.154例患者（79.0%）目前有性伴;118例（86.8%）患者最近6个月内每次性行为均使用安全套,123例（91.8%）患者在最近一次的性行为中使用了安全套.HSV-1的IgG抗体阳性率为84.1%（164/195）;HSV-2的IgG抗体阳性率为13.3%（26/195）.合并感染HSV-1和HSV-2的有14例（7.2%）.单因素logistic回归分析显示HSV-2感染与婚姻状况有关（OR=7.41;95%CI：2.42～22.73;P〈0.01）,未婚患者HSV-2感染率（46.7%,7/15）高于已婚者（10.6%,19/180）.结论 当地艾滋病患者中存在一定比例的HSV-1和HSV-2感染者.艾滋病患者的HSV-2感染与婚姻状态有关.Objective To determine the prevalence of herpes simplex virus（HSV）and its correlates among HIV/AIDS patients in a county of Shanxi.Methods All HIV-infected patients in a county in Shanxi province who were receiving antiretroviral treatment（ART） were included in this study.Participants were interviewed using standard questionnaires.Serum samples were tested to determine HSV-1 and HSV-2 infections.Results A total of 195 AIDS patients were recruited and 195 blood samples were collected.Among 195 AIDS patients.189（96.9%）were farmers;116（59.5%）were men while 79 were women：146（74.9%）were between 20-50 years old：180（92.3%）were married.The maior routes of HIV transmission were blood/plasma donation or transfusion（176 patients,90.3%）.CD4＋ T cell counts were between（1-1531）×106 cells/L（（323.6±14.8）×106 cells/L）,with 44（26.5%）patients＇ CD4＋ T cell counts less than 200×106 cells,/L Of which,154 patients（79.0%）had sexual partners.86.8% （118 patients）consistently used condoms during the past 6 months,while for the last sexual act,91.8% （123 patients）used condoms.For anti-HSV-1 status,there were about 164 patients（84.1%）were positive,and 26（13.3%）were positive for anti-HSV-2.While,14（7.2%）were positive for both anti-HSV-1 and anti-HSV-2. Logistic regression analysis indicated that marital status were correlated with HSV-2 infection （ OR = 7.41 ; 95% CI： 2. 42 - 22. 73 ; P 〈 0. 01 ）. No socio-demographic and sexual characteristics were identified to be correlated with HSV-1 infection. Conclusion A substantial proportion of AIDS patients in a rural county of Shanxi province of China were co-infected with HSV-1 and/or HSV-2. Marital status was correlated with HSV-2 infection.

关 键 词：获得性免疫缺陷综合征 单纯疱疹病毒属 感染 因素分析 统计学 

分 类 号：R51[医药卫生—内科学]