情绪和生理应激对大鼠行为及血粘度的影响  

Distinct effects of emotional and physiological stress on the behavior and blood viscosity of rats

作　　者：刘莉[1] 凤林谱[1] 刘新民[1] 

机构地区：[1]皖南医学院心理学教研室,安徽芜湖241002

出　　处：《皖南医学院学报》2010年第3期176-178,共3页Journal of Wannan Medical College

基　　金：2008年皖南医学院中青年科研基金项目(WK200839)

摘　　要：目的:探讨不同应激时程(1h,24h,1w和4w)、不同应激方式对大鼠探究、修饰、攻击行为的影响及血粘度低切、中切、高切的变化。方法:实验采用空瓶刺激法及无空瓶刺激法等,将96只Wistar大鼠随机分为情绪应激组、生理应激组、对照组,对大鼠进行心理和生理应激、行为学观测后,立即处死大鼠,测定血粘度。结果:第1、3、4周情绪应激组大鼠攻击行为分数明显高于生理应激组(P<0.05);第1、3周时探究行为ES组明显高于PS组,差异有显著性(P<0.05)。在全血粘度中切速率下,24h时ES组明显高于PS组(P<0.05);在全血粘度高切速率下,1h和24h时ES组明显高于PS组(P<0.05)。结论:情绪应激组大鼠比生理应激组大鼠行为活动量大、血粘度值高,提示不同应激方式对大鼠的行为及血液流变学的改变是不同的。Objective：To investigate the distinct effects of emotional and physiological stress at separated time-history（1 h,24 h,1 w and 4 w） on behaviors including exploring,grooming,attacking and the change of the blood viscosity（5 s-1,50 s-1,100 s-1） in rats.Methods：Ninety-six Wistar rats were randomly divided into groups of emotional stress[（ES） （1 h ES,24 h ES,1 w ES and 4 w ES,n=8）],physiological stress [（PS）（ 1 h PS,24 h PS,1 w PS and 4 w PS,n=8）] and controls[（C）（1 h,24 h,1 w,and 4 w,n=8 each）],and after the observation of the rats concerning emotional and physiological stress and behaviors,all rats were killed for determination of the blood viscosity.Results：At week 1,3 and 4,total scores of attacking behavior in emotionally stressed rats were significantly higher than those of the physiologically stressed（P0.05）.The exploring behavior of rats became intensified at 1 w and 3 w in ES groups as compared with PS group,with evident statistical difference（P0.05）.By examination of the median shear blood viscosity,ES at 24 h was higher than that of PS,with similar finding of ES at 1 h and 24 h（P0.05）.Conclusion：Compared with PS rats,ES rats behaved more actively and showed higher blood viscosity,which suggests that different stress would lead to different behaviors and various change in hemorheology.

关 键 词：情绪应激 生理应激 行为 血粘度 

分 类 号：R331.11[医药卫生—人体生理学] R395.6[医药卫生—基础医学]