床旁快速测定神经末端脑钠肽在非ST段抬高急性冠脉综合征中的诊断价值  

The diagnostic application of ultra-rapid bedside measurement of NT-pro BNP in non-ST elevation actue coronary syndrome

作　　者：李燕[1] 卢彩兰[1] 刘晋[1] 马涛[1] 陈青[1] 

机构地区：[1]山西医科大学第二医院,山西太原030001

出　　处：《临床医药实践》2010年第6期415-417,共3页Proceeding of Clinical Medicine

摘　　要：目的:观察不同临床类型急性冠状动脉综合征(ACS)的神经末端脑钠肽(NT-proBNP)的水平及其与心肌坏死标志物的相关性,进一步探讨其临床意义。方法:选择急诊科收治的24 h内发病的ACS患者81例,其中非ST段抬高心肌梗死组42例,不稳定型心绞痛组39例,健康对照组28例,采用罗氏公司的心脏标志物分析仪,分别测定各研究组的血NT-proBNP及肌钙蛋白T(cTnT)浓度。结果:非ST段抬高心肌梗死组NT-proBNP浓度(2 256±374)pg/mL显著高于不稳定型心绞痛组(1 285±238)pg/mL(P<0.01),两组NT-proBNP的浓度均高于健康对照组(276±31)pg/mL(P<0.01),差异均有显著性;非ST段抬高心肌梗死组NT-proBNP升高程度与cTnT呈正相关(P<0.01)。结论:NT-proBNP是一种灵敏且能反映心肌缺血损伤的指标,它的增高有助于对非ST段抬高的ACS患者进行危险分层和恰当的早期干预。Objectives：To explore the relationship between serum level of N-terminal pro-B-type natriuretic peptide（NT-proBNP） and clinical phenotypes of actue coronary syndrome（ACS） and the correlation between NT-proBNP and troponin T（cTnT）.Methods：Eighty-one patients with ACS in 24 hours onset were enrolled in this study,including non-ST elevation myocardial infarction（n=42）,unstable angina pectoris（n=39）,and health controls（n=28）.Serum levels of NT-proBNP and cTnT were measured by roche cardiac reader in all patients.Results：The level of NT-proBNP in non-ST elevation myocardial infarction（2 256±374） pg/mL was significantly than that in unstable angina pectoris（1 285±238） pg/mL（P〈0.01）,the level of NT-proBNP in two groups was highly than that in health controls（276±31） pg/mL（P〈0.01）,there were significant difference in three groups（P〈0.01）.The NT-proBNP level were highly correlated with cTnT in non-ST elevation myocardial infarction（P〈0.01）.Conclusion：NT-proBNP is a sensitive index and it may reflect degree of myocardial necrosis.The high NT-proBNP level is conduce to dangerous layer and early intervention in non-ST elevation actue coronary syndrome.

关 键 词：神经末端脑钠肽 非ST段抬高急性冠脉综合征 诊断价值 

分 类 号：R543.3[医药卫生—心血管疾病]