不同肥胖标准的PCOS患者脂代谢的对比研究  

Comparative study of lipid metabolism in PCOS patients with different obesity standards

作　　者：黄卡立[1] 蒋凤艳[2] 黎红芳[2] 

机构地区：[1]广西壮族自治区人口和计划生育研究中心,南宁530021 [2]广西医科大学,南宁530021

出　　处：《中国临床新医学》2010年第5期414-417,共4页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：广西科技厅自然科学基金课题(桂科基NO:0663025);广西教育厅课题(编号:200510024);广西教育厅研究生科研创新项目(编号:2006105981002M18)

摘　　要：目的探讨不同肥胖标准的多囊卵巢综合征(PCOS)患者脂代谢情况,为PCOS患者心血管疾病的防治提供理论依据。方法以体重指数(BMI)≥24kg/m^2为肥胖标准,将PCOS患者分为肥胖A组和非肥胖A组;以腰臀比(WHR)≥0.8为肥胖标准,将PCOS患者分为肥胖B组和非肥胖B组;以BMI≥24kg/m^2和WHR≥0.8为肥胖标准,将PCOS患者分为肥胖C组和非肥胖C组。测定各组甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)、脂蛋白a(Lp-a)等指标水平。结果 (1)PCOS肥胖A组的TG明显高于非肥胖A组(P<0.05),肥胖B组的TC、LDL-C明显高于非肥胖B组(P<0.05),PCOS肥胖C组的TG明显高于非肥胖C组(P<0.05);(2)多因素分析显示WHR、BMI均与HDL-C相关(P<0.05)。结论 PCOS患者脂代谢异常与肥胖有密切联系,应积极治疗和监测PCOS肥胖患者,以防止和减少其心血管疾病的发生与发展。Objective To study the lipid metabolism of polycystic ovary syndrome （PCOS） patients with the different obesity standards, and to provide the basis for prevention and treatment of cardiovascular disease in these women. Methods With body mass index （BMI） ≥ 24 kg/m2 for the obesity standards, PCOS patients were divided into obese A group and non-obese A group;With waist-hip ratio （WHR） 1〉 O. 8 for the obesity standards, PCOS pa- tients were divided into obese B group and non-obese B group;With BMI ≥24 kg/m2 and WHR I〉 0. 8 for the obesity standards, PCOS patients were divided into obese C groups and non-obese C group. The levels of triglycerides （TG）, total cholesterol（TC）, high density lipoprotein cholesterol（ HDL-C ）, low density lipoprotein cholesterol （ LDL- C ）, apolipoprotein （a） -1 （ ApoA1 ）, apolipoprotein （b） （ ApoB ） and lipoprotein a （Lp-a） were measured in these patients. Results （ 1 ） The TG level in obese A group was higher than that in non-obese A group （P 〈 0. 05 ）, the TC and LDL-C level in obese B group was higher than that in non-obese B group （ P 〈 0. 05 ） ; The TG level in obese C group was higher than that in non- obese C group （P 〈0.05） ; （2） Multivariate analysis showed that WHR and BMI were associated with HDL-C （P 〈 0. 05 ）. Conclusion In PCOS patients abnormal lipid metabolism and obesity are closely linked. Obese PCOS patients should be morniterd and treated to prevent and reduce the occurrence and development of cardiovascular disease.

关 键 词：多囊卵巢综合征 肥胖 脂代谢 心血管疾病 

分 类 号：R711.75[医药卫生—妇产科学]