IHC-72对心肌细胞慢钙通道的影响  

Effects of 3,6-dimethylamino-dibenzopyriodonium edetate on slow calcium channels of myocardium

作　　者：陈江斌[1] 李庚山[1] 许家俐[1] 蒋锡嘉[1] 

机构地区：[1]湖北医科大学附属第一医院心血管病研究室,武汉430060

出　　处：《心电学杂志》1999年第1期22-24,共3页Journal of Electrocardiology(China)

摘　　要：为了解3,6二甲氨基二苯骈碘杂环依地酸盐(IHC-72)对家兔浦肯野纤维慢钙通道的浓度依赖性效应,采用双微电极电压钳制术,观察IHC-72对慢钙电流(I_(Ca))的作用.结果显示:2.54μmol/LHC-72对I_(Ca)无影响(P>0.05);25.4、101.6μmol/LIHC-72对I_(Ca)的抑制率分别为20%和54.6%(P均<0.01),但都不使I-V曲线的峰值发生偏移;而0.5、5μmol/L维拉帕米对I_(Ca)的抑制率分别为23%和57.48%.表明IHC-72能浓度依赖性阻滞I_(Ca),且25.4、101.6μmol/LIHC-72对I_(Ca)的抑制与0.5、5μmol/L维拉帕米相当.Concentration-dependent effects of 3,6-dimethylamino-dibenzo-pyiodonium edelate(lHC-72) on slow calcium channel of isolated rabbit purkinje fibres were studied. Using two microelectrode voltage clamp technique, we studied effects of IHC - 72 on slow calcium channel current(lca),Result showed that: IHC - 72 in 2.54μmol/L did not affect Ica (P > 0.05) .IHC - 72 in 25.4 and 101. 6μmol/ L reduced Ica by 20% and 54.6% (P <0.01) , respectively, without shifting of current-voltage (I-V) curve of peak Ica: verapamil in 0.5, 5μmol/L reduced Ica by 23% and 57.5% (P < 0.01), respectively. It is concluded that IHC-72 could inhibit Ica in a concentration-dependent manner, and inhibitory effects of IHC - 72 in 25.4, 101.6μmol/L is almost equal to that of verapamil in 0.5,5μol/L .

关 键 词：碘杂环化合物 慢钙电流 心肌细胞 抗心律失常 

分 类 号：R972.2[医药卫生—药品]