舒利迭对哮喘缓解期患儿肺功能影响及安全性评价  

Influence of Seretide to Pulmonary Function on Asthmatic Children in Remission Period and Safety Evaluation

作　　者：方清 

机构地区：[1]湖南省岳阳市平江县妇幼保健院儿科,湖南岳阳414500

出　　处：《中外医疗》2010年第11期12-12,14,共2页China & Foreign Medical Treatment

摘　　要：目的探讨舒利迭对哮喘缓解期患儿肺功能影响及安全性评价。方法收集哮喘缓解期患儿60例和健康儿30例。哮喘缓解期患儿治疗前和治疗6个月后采取外周血,留取血清备测皮质醇,检测肺功能和骨密度改变。健康儿采取外周血,留取血清备测皮质醇,检测骨密度。结果哮喘缓解期患儿治疗后FEV1/FVC和PEF均高于治疗前,差异有统计学意义。哮喘缓解期患儿治疗后皮质醇和骨密度与治疗前和健康儿比较,差异无统计学意义。结论舒利迭能改善哮喘缓解期患儿气道高反应性,对肾上腺皮质功能和骨密度未见显著影响。Objective Investigated influence of Seretide to pulmonary function on asthmatic children in remission period and safety evaluation.Methods Collected 60 cases of asthmatic children in remission period and 30 cases of healthy children.Peripheral blood of asthmatic children in remission period before treatment and after treatment the June were taken to detect cortisol.Lung function and bone density were detected in asthmatic children in remission period before treatment and after treatment the June.Peripheral blood of healthy children were taken to detect cortisol.Lung function and bone density were detected.Results Asthmatic children in remission period after treatment FEV1/FVC and PEF were higher than before treatment,and the difference were statistically significant.Compared with before treatment and healthy children,the difference was not statistically significant of cortisol and bone mineral density on asthmatic children in remission period after treatment.Conclusion Seretide could improve airway hyper-reactivity of asthma in children in remission period,but adrenal function and bone density had not significant effect.

关 键 词：哮喘 舒利迭 肺功能 血皮质醇 骨密度 

分 类 号：R974[医药卫生—药品]