^(201)Tl、^(123)I-BMIPP心肌SPECT显像对存活心肌的评价(与^(18)F-FDG PET显像对比研究)  

A comparative study of 201 Tl, 123 I BMIPP myocardial SPECT with 18 F FDG PET for evaluation of viable myocardium

作　　者：王丽娟[1,2] 越智宏畅 

机构地区：[1]中国医科大学第一临床学院循环内科 [2]日本国大阪市立大学医学部附属病院

出　　处：《中华核医学杂志》1999年第1期26-28,共3页Chinese Journal of Nuclear Medicine

摘　　要：目的通过与１８Ｆ脱氧葡萄糖（ＦＤＧ）ＰＥＴ显像对比，探讨２０１Ｔｌ、１２３Ｉβ甲基碘苯脂十五烷酸（ＢＭＩＰＰ）心肌ＳＰＥＣＴ显像在评价存活心肌中的临床价值。方法３１例急性心肌梗塞患者，将其左心室分成９个节段，采用４级目测评分法测定并比较２０１Ｔｌ及１２３ＩＢＭＩＰＰ的聚集（摄取正常＝０，严重减少＝３）。在２０１ＴｌＳＰＥＣＴ所示血流低下部位，定性及定量测定１８ＦＦＤＧ摄取，同时将２０１Ｔｌ、１２３ＩＢＭＩＰＰＳＰＥＣＴ及１８ＦＦＤＧＰＥＴ所见与室壁运动作对比分析。结果血流灌注低下的１１２个节段中，２０１Ｔｌ、１２３ＩＢＭＩＰＰ匹配的节段为４２９％（４８个），不匹配的节段为５７１％（６４个）；且２０１Ｔｌ、１２３ＩＢＭＩＰＰ不匹配节段的９２２％和匹配节段的５２１％（２０１Ｔｌ、１２３ＩＢＭＩＰＰ均为严重缺损者占３３３％），１８ＦＦＤＧＰＥＴ显示有心肌活力。在左室无运动或者反向运动的节段中，１８ＦＦＤＧＰＥＴ判断有活力者为６５６％，２０１Ｔｌ、１２３ＩＢＭＩＰＰＳＰＥＣＴ判断有活力者为５００％。结论联合２０１Ｔｌ、１２３ＩＢＭＩＰＰ心肌ＳＰＥＣＴ判断存活心肌是有用的，但与?Objective To evaluate the value of 201 Tl, 123 I BMIPP myocardial SPECT for detection of viable myocardium via comparative study with 18 F FDG PET Methods The left ventricular myocardium was divided into 9 segments in 31 patients with acute myocardial infarction (AMI) Uptakes of 201 Tl and 123 I BMIPP were visually scored as follows: 0=normal uptake, 3=severe reduction, and the scores of two tracers were compared with each other in each segment The 18 F FDG uptakes were determined visually and quantitatively in the segments with hypoperfusion detected by 201 Tl, 123 I BMIPP SPECT Furthermore, comparative analysis of 18 F FDG PET and 201 Tl, 123 I BMIPP SPECT findings with wall motion was also performed Results In 112 segments with hypoperfusion, segments of 201 Tl, 123 I BMIPP uptake match were 42.9% (48), and the mismatch were 57 1% (64) The 18 F FDG PET viable rate constituted 92 2% of segments with 201 Tl, 123 I BMIPP mismatch and 52 1% (33 3% of segments with severe reduction in uptake of 201 Tl and 123 [KG*7/9]I BMIPP) of segments with 201 Tl, 123 I BMIPP match As to the segments with akinesis～dyskinesis of wall motion, 65 6% were viable by the 18 F FDG PET, and 50 0% were viable by the 201 Tl, 123 I BMIPP SPECT Conclusions 201 Tl, 123 I BMIPP myocardial SPECT is useful for evaluating viable myocardium, but it may underestimate the viable myocardium as compared with 18 F FDG PET

关 键 词：BMIPP 心肌梗塞 铊201 碘123 SPECT 

分 类 号：R817.42[医药卫生—影像医学与核医学] R542.220.4[医药卫生—放射医学]