不同标准空腹血糖受损人群葡萄糖负荷后血糖代谢特征及相关因素分析  

Risk Factors and Metabolism Characteristics of Blood Glucose after Glucose Load in Different Impaired Fasting Glucose Populaton

作　　者：蒋升[1] 李新岩[2] 严丽君[3] 庞进才[4] 谢自敬[1] 

机构地区：[1]新疆医科大学第一附属医院内分泌科,新疆乌鲁木齐市830054 [2]新疆医科大学第五附属医院内分泌科 [3]武警新疆总队医院内分泌科 [4]新疆生产建设兵团农六师103团医院

出　　处：《中国全科医学》2010年第14期1566-1568,共3页Chinese General Practice

基　　金：新疆维吾尔自治区自然科学基金项目(200421124)

摘　　要：目的探讨2种标准空腹血糖受损(IFG)人群葡萄糖负荷后血糖代谢特点及相关危险因素。方法对3828例40岁以上居民及职工进行糖尿病流行病学调查和实验室检查。对空腹血糖(FPG)≥5.6mmol/L者行75g葡萄糖负荷试验,分析负荷后2h血糖(PPG)代谢情况及其相关危险因素。结果3828例调查对象中,5.6mmol/L≤FPG<7.0mmol/L的IFG患者627例(A组),6.1mmol/L≤FPG<7.0mmol/L的IFG患者245例(B组)。A组人群中,糖耐量减低(IGT)的患病率为37.00%(232/627),其中女性IGT患病率(23.76%)显著高于男性(13.23%),差异有统计学意义(P<0.05);2型糖尿病(T2DM)患病率为13.88%(87/627),女性T2DM患病率(9.52%)显著高于男性(4.63%),差异有统计学意义(P<0.05);Logistic回归分析显示,该IFG人群PPG升高的危险因素为FPG、年龄、饮酒、收缩压和体质指数(BMI)。B组人群中,IGT的患病率为41.22%(101/245),其中女性IGT患病率(25.71%)显著高于男性(15.51%),差异有统计学意义(P<0.05);T2DM患病率为20.82%(51/245),其中女性T2DM患病率(11.84%)显著高于男性(8.98%),差异有统计学意义(P<0.05);Logistic回归分析显示,该IFG人群PPG升高的危险因素为FPG、年龄和BMI。结论以5.6mmol/L和6.1mmol/L为切点的IFG阶段,PPG代谢异常率分别为50.88%和62.04%,共同且可控危险因素为体质量。Objective To exaplore the risk factors and metabolism characteristics of blood glucose after glucose load （PPG） in different impaired fasting glucose （IFG） populaton.Methods A cross-sectional study was conducted in 3 828 residents above 40 years old.Oral glucose tolerance test（OGTT,75-g glucose） was done in residents with fasting blood glucose（FPG） ≥5.6 mmol/L.The risk factors and metabolism characteristics of PPG were analyzed.Results （1）The prevalence of IGT in IFG（FPG≥5.6 mmol/L） population was 37.00%,higher in female（23.76%） than in male（13.23%）;That of T2DM was 13.88%,higher in female （9.52%） than in male（4.63%）.Regression analysis revealed that FPG,age,SBP and BMI were risk factors of PPG in IFG.The prevalence of IGT in IFG（FPG≥6.1 mmol/L） population was 41.22%,higher in female（25.71%） than in male（15.51%）;That of T2DM was 20.82%,higher in female（11.84%） than in male（8.98%）.Regression analysis revealed that the FPG,Age and BMI were risk factors of PPG in IFG.Conclusion The prevalence of abnormal PPG in different IFG population are 50.88% and 62.04%,the common risk factor that can be controlled is body weight.

关 键 词：空腹血糖受损 2型糖尿病 葡萄糖代谢障碍 危险因素 

分 类 号：R587.1[医药卫生—内分泌]