沐舒坦经超声电导透皮给药治疗小儿支气管肺炎的临床疗效观察  

Effect of Mucosolvan by Ultrasound Conductance Cutaneous Penetration on Pediatric Bronchopneumonia

作　　者：高志华[1] 李峰[1] 李雅杰[1] 

机构地区：[1]河北省唐山市协和医院儿科,063000

出　　处：《中国全科医学》2010年第14期1585-1586,共2页Chinese General Practice

摘　　要：目的探讨沐舒坦经超声电导透皮给药治疗小儿支气管肺炎的临床疗效。方法将319例小儿支气管肺炎患儿随机分为3组,将沐舒坦注射液分别以超声电导透皮(Ⅰ组,n=107)、雾化吸入(Ⅱ组,n=103)、静脉推注(Ⅲ组,n=109)3种方式给药,对比分析3种给药方式的疗效及不良反应。结果Ⅰ组显效73例(68.22%),好转32例(29.91%),无效2例(1.87%);Ⅱ组显效55例(53.40%),好转37例(35.92%),无效11例(10.68%);Ⅲ组显效38例(34.86%),好转47例(43.12%),无效24例(21.02%),3组患儿的疗效间差异有统计学意义(Hc=30.739,P<0.05)。组间两两比较,Ⅰ组与Ⅱ组的疗效间差异有统计学意义(P<0.05),Ⅰ组与Ⅲ组的疗效间差异有统计学意义(P<0.05),Ⅱ组与Ⅲ组的疗效间差异也有统计学意义(P<0.05)。结论沐舒坦经超声电导透皮给药具有高效、低创伤、无痛苦、易操作及可配合性高的优点,是儿科临床较有前景的给药途径。Objective To discuss the curative effect of mucosolvan by ultrasound conductance cutaneous penetration on pediatric bronchopneumonia.Methods A total of 319 children with bronchopneumonia were randomized into groups Ⅰ（mucosolvan administrated by ultrasound conductance cutaneous penetration）,Ⅱ（by inhalation）,Ⅲ（by intravenous injection）.The effectiveness and adverse reactions were analyzed in 3 groups.Results In group Ⅰ,73 had obvious effect （68.22%）,32 had improvement （29.91%）,2 had no effect （1.87%）;in group Ⅱ,55（53.40%）,37（35.92%）,11（10.68%）,respectively;in group Ⅲ,38 （34.86%）,47 （43.12%）,24 （21.02%）,respectively,the difference was significant between 3 groups （Hc=30.739,P〈0.05）.And there was significant difference in effectiveness between groups Ⅰ,Ⅱ（P〈0.05）,between groups Ⅰ and Ⅲ （P〈0.05）,between groups Ⅱ and Ⅲ（P〈0.05）.Conclusion Mucosolvan administrated by ultrasound conductance cutaneous penetration,with high efficiency,low trauma,without pain and easy to operate,is a promising route of administration in pediatric clinic.

关 键 词：沐舒坦 投药 皮肤 支气管肺炎 治疗结果 

分 类 号：R725.631[医药卫生—儿科]