食盐碘化状态下甲状腺疾病相关因素的研究  

Impact of Salt Iodization on Thyroid Disease

作　　者：陈彬[1] 吕肖锋[1] 张星光[1] 王雅杰[2] 

机构地区：[1]北京军区总医院内分泌科,北京市100700 [2]首都医科大学附属北京天坛医院检验科

出　　处：《中国全科医学》2010年第15期1637-1638,共2页Chinese General Practice

摘　　要：目的探讨目前食盐碘化状态下成人甲状腺疾病的相关因素。方法随机选取2007年1—6月内分泌与代谢病专科门诊甲状腺肿大的初诊患者150例,测定甲状腺功能、甲状腺自身抗体以及尿碘质量浓度。结果 150例甲状腺肿大患者中60例诊断为格雷夫斯病(Graves病),40例为慢性淋巴细胞性甲状腺炎,25例为单纯性甲状腺肿,17例为结节性甲状腺肿,8例为亚急性甲状腺炎。其中男43例,女107例。结节性甲状腺肿患者平均年龄明显高于其他各组,差异有统计学意义(P<0.01),各组患者尿碘质量浓度比较,差异无统计学意义(P>0.05)。甲状腺肿大患者甲状腺过氧化物酶抗体(TPOAb)与甲状腺球蛋白抗体(TGAb)阳性率分别为51%与42%,甲状腺肿大患者TPO-Ab水平与TGAb水平呈正相关(r=0.717,P<0.01)。结论在目前超足量的碘营养状况下,碘缺乏已不再是引起甲状腺肿大的主要原因。长期暴露于高碘下,甲状腺自身抗体与TGAb水平均增加,易患人群容易发生自身免疫性甲状腺疾病。Objective To explore the causes for adult thyroid goiter under the current status of iodine nutrition.Methods Thyroid function,thyroid autoantibodies and urinary iodine concentration were measured in 105 newly-diagnosed thyroid goiter patients randomly chosen from Jan 2007 to June.Results Sixty of 150 thyroid goiter patients （43 males,107 females）were diagnosed as Graves disease,40 as chronic lymphocytic thyroiditis,25 as simple goiter,17 as nodular goiter,8 as subacute thyroiditis.The average age of nodular goiter patients was significantly higher than that of other groups （P0.01）.No significant difference in urine iodine concentration between each group （P0.05）.The positive rates of thyroid peroxidase antibody （TPOAb） and thyroglobulin antibody （TGAb） were 51%,42%,respectively,and TPOAb level positively correlated with TGAb （r=0.717,P0.01）.Conclusion In current status of super-sufficient quantities of iodine nutrition,iodine deficiency is no longer the main cause of goiter.Long-term exposed to iodine,susceptible population is prone to artoimmune thyroid diseases.

关 键 词：甲状腺疾病 碘 甲状腺功能试验 

分 类 号：R581[医药卫生—内分泌]