拆方对鸭掌散汤剂中甘草酸含量影响的研究  

Study on the Influence of Decomposing on the Glycyrrhizic Content of Acid in Yazhangsan

作　　者：武孔云[1,2] 梁光义[3,2] 杨娜[3] 叶世芸[3] 靳凤云[3] 贺祝英[3] 

机构地区：[1]贵阳学院,贵州贵阳550005 [2]贵州省中国科学院天然产物化学重点实验室,贵州贵阳550002 [3]贵阳中医学院,贵州贵阳550002

出　　处：《时珍国医国药》2010年第5期1041-1042,共2页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(No.30460154)

摘　　要：目的探讨鸭掌散传统汤剂中甘草酸的含量是否与方中白果与麻黄有关,为鸭掌散组方提供科学依据。方法对甘草酸含量测定进行方法学考察;将鸭掌散方中的白果及麻黄分别从方中拆除后制备成传统汤剂,并测定其甘草酸含量,对实验数据进行数理统计分析。结果拆方后甘草酸含量经数理统计分析有明显差异。结论鸭掌散传统汤剂中甘草酸含量不受方中白果有无的影响;麻黄的缺失会导致鸭掌散传统汤剂中甘草酸含量显著下降。Objective To investigate the relationship between the content of glycyrrhizic acid and Semen Ginkgo and Herba Ephedrae in the traditional decoction,and to provide a scientific basis for the composition of Yazhangsan Decoction.Methods We conducted this study by determining the content of glycyrrhizic acid with the treatment of removing Semen Ginkgo or Herba Ephedrae,leaving it as the traditional decoction.After that,we conducted the statistic analysis on the empirical data.Results After decomposing the recipes,the content of glycyrrhizic acid significantly changed..Conclusion The content of glycyrrhizic acid in the traditional decoction is not influenced by Semen Ginkgo,and the contents of glycyrrhizic acid in the traditional decoction is not influenced by Herba Ephedrae.

关 键 词：鸭掌散 甘草酸 传统汤剂 颗粒汤剂 高效液相色谱 

分 类 号：R289.1[医药卫生—方剂学]