鹅不食草醋酸乙酯部位化学成分的研究  

Study on Chemical Constituents from Ethyl Acetate Fraction of Centipeda minima

作　　者：吴和珍[1] 刘玉艳[1] 杨艳芳[1] 肖梦媛[1] 

机构地区：[1]湖北中医学院"中药资源与中药复方"省部共建教育部重点实验室,湖北武汉430065

出　　处：《时珍国医国药》2010年第5期1096-1098,共3页Lishizhen Medicine and Materia Medica Research

基　　金：教育部科学技术研究重点项目(No.209079)

摘　　要：目的研究鹅不食草全草的化学成分。方法利用硅胶柱色谱、AgNO3硅胶柱色谱、半制备高效液相色谱和葡聚糖凝胶ToyopearlHW-40F凝胶渗透进行分离、纯化。根据理化性质和现代波谱技术并辅以化学方法进行结构鉴定。结果从鹅不食草醇提取物的醋酸乙酯萃取层中得到9个化合物,分别鉴定为蒲公英甾醇(Ⅰ);β-谷甾醇(Ⅱ);β-胡萝卜苷(Ⅲ);2-(1-羟基丙烷)-4-甲酚(Ⅳ);短叶老鹳草素(Ⅴ);2β-羟基-2,3-二氢-6-O-当归酰多梗白菜菊素(Ⅵ);二氢堆心菊灵(Ⅶ);堆心菊灵(Ⅷ);豆甾醇-3-O-β-D-吡喃葡萄糖苷(Ⅸ)。结论化合物Ⅳ、Ⅵ为首次从石胡荽属植物中分离得到。Objective To study the chemical constituents of Centipeda minima.Methods Isolation and purification were carried out by silica gel column chromatography,semi-preparative reversed-phase HPLC and Toyopearl HW-40F.Compounds were identified and elucidated by spectral and chemical methods.Results Nine compounds were obtained from ethyl acetate extract fraction.Their structures were identified as taraxasterol（Ⅰ）,β-sitosterol（Ⅱ）,β-sitosterylpalmitate（Ⅲ）,2-（1-hydroxypropan-2-yl）-4-methylphenol（Ⅳ）,Brevilin（Ⅴ）,2β-hydroxyl-2,3-dihydrogen-6-O-angeloplenolin（Ⅵ）,11,13-dihydrohelenalin（Ⅶ）,helenalin（Ⅷ）,stigmasterol-3-O-β-D-glucopyranoside（Ⅸ）.Conclusion Compound Ⅳand Ⅵ were isolated from the plants of Centipeda minima for the first time.

关 键 词：鹅不食草 结构鉴定 

分 类 号：R284.1[医药卫生—中药学]