PTEN在神经元损伤和脑功能障碍中的作用  

Roles of PTEN in Neuronal Injury and Brain Disorders

作　　者：吴宏日[1] 王云超[1] 蔡其燕[2] 

机构地区：[1]第三军医大学学员旅二队,重庆400038 [2]第三军医大学组织学与胚胎学教研室,重庆400038

出　　处：《医学综述》2010年第11期1607-1610,共4页Medical Recapitulate

摘　　要：磷酸酶与张力蛋白同源物基因(PTEN)是定位于10q23的具有双重磷酸酶活性的抑癌基因,其缺失或失活常会导致肿瘤的发生。PTEN在神经系统表达广泛,它能分别以其脂质和蛋白质磷酸酶活性通过Akt信号通路及与膜受体N-甲基-D-天冬氨酸受体和五羟色胺2c受体的相互作用,调节神经元的损伤和脑功能障碍的发生。因此,对PTEN功能的进一步研究将使其在肿瘤和神经疾病的治疗上具有潜在的临床应用价值。Phosphatase and tensin homolog gene（PTEN）was identified as a tumor suppressor located in 10q23 with dual phosphatase activity,its deleted or inactivation often leads to cancer.PTEN express widely in nervous system,which lipid and protein phosphatase activities can regulate neuronal injury and incidence of brain dysfunction through Akt signaling pathway and interaction with the membrane receptor N-methyl-D-aspartate receptor and 5-hydroxytryptamine2c receptor.So,the further study of PTEN will have potential clinical value in the treatment of cancer and neurological diseases.

关 键 词：磷酸酶与张力蛋白同源物基因 神经元损伤 神经再生 神经精神障碍 

分 类 号：R322.81[医药卫生—人体解剖和组织胚胎学]