软腭与阻塞性睡眠呼吸暂停低通气综合征的关系  

The Relation between Soft Palate and Obstructive Sleep Apnea-Hypopnea Syndrome

作　　者：黄轶[1] 周永[1] 

机构地区：[1]广西医科大学附属第一医院耳鼻咽喉头颈外科,南宁530021

出　　处：《医学综述》2010年第11期1708-1711,共4页Medical Recapitulate

摘　　要：阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的病因是复杂的和多因素的。大量研究表明,软腭的形态和组织病理学的很多改变都与OSAHS密切相关,软腭后移造成腭帆间隙消失,呼吸道扩张肌的肌纤维分布异常导致的肌肉活动减弱,软腭中脂肪分布增加,肌肉呈现的炎症改变及腭咽部神经纤维的损伤等一系列解剖形态及显微结构上的诸多改变,构成了OSAHS发病机制中的重要环节。但软腭与OSHAS发病更为确切的因果联系,有待于作大规模的临床调查,在分子水平更进一步地研究。The pathogeny of obstructive sleep apnea-hypopnea syndrome were complex with multi-factors.Based on a large number of studies,it was considered that some morphology and histopathologic changes of soft palate were related to OSAHS.These changes,including a narrow interspace behind the velum palatinum,a attenuated musculation of airway dilator from anomalism in the distribution of muscle fiber,fat tissue increasing,inflammation reaction,the injury of nerve fibers and so on,which played significant roles in the cause of OSAHS.But as for exactly how the two were connected still required further researches at molecular level on account of major investigations and analysises.

关 键 词：软腭 阻塞性睡眠呼吸暂停低通气综合征 病理 

分 类 号：R322.42[医药卫生—人体解剖和组织胚胎学] R361.2[医药卫生—基础医学]