人工通便对早产儿喂养不耐受及血清胃泌素水平的影响  

Effects of Artificial Defecation on the Feeding Intolerance and Level of Serum Gastrin in Premature Infants

作　　者：孙鸿燕[1] 董文斌[2] 张连玉[2] 熊安芳[2] 卢佑英[2] 

机构地区：[1]四川泸州医学院护理学院,四川泸州646000 [2]泸州医学院附属医院新生儿科

出　　处：《中华妇幼临床医学杂志（电子版）》2010年第3期192-194,共3页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

摘　　要：目的探讨人工通便对早产儿喂养不耐受及血清胃泌素水平的影响。方法选取2008年4月至2009年2月泸州医学院附属医院新生儿科收治的需行鼻饲奶粉喂养早产儿30例为研究对象,随机将其分为人工通便组(n=15)和对照组(n=15)(本研究遵循的程序符合泸州医学院附属医院人体试验委员会所制定的伦理学标准,得到该委员会批准,分组征得受试对象监护人的知情同意,并与之签署临床研究知情同意书)。采用放射免疫分析法测定血清胃泌素水平,同时观察两组患儿喂养不耐受情况。结果人工通便组早产儿喂养不耐受发生率较对照组低(26.67%vs.66.67%),达全胃肠喂养及恢复出生时体重时间短[(10.21±2.81)dvs.(16.59±3.37)d,(9.39±3.62)dvs.(14.17±2.54)d],血清胃泌素水平增高,两组比较,差异有显著意义(P<0.01)。结论人工通便可促进早产儿胃泌素分泌,可有效减少早产儿喂养不耐受的发生。Objective To study effects of artificial defecation on the feeding intolerance of and serum gastrin level in premature infants. Methods From April 2008 to February 2009, 30 premature infants with feeding intolerance who were admitted to the Department of Newborn, Affiliated Hospital of Luzhou Medi- cal College and received nasal feeding of milk powder were enrolled in this study. They were randomly divided into artificial defecation group （n= 15） and control group （n= 15）. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Affiliated Hospital of Luzhou Medical College. Informed consent was obtained from the parents of each participating neonate. Serum gastrin levels were measured by radio immunoassay, and the occurrence of feeding intolerance were investigated in both groups. Results The occurrence of feeding intolerance of artificial defecation group was lower than that of control group （26.67% vs. 66.67o//00）, the time of recovering to their birth weight and reaching the whole stomach intestine feeding were significantly decreased in artificial defecation groupE（10.21 ± 2.81） d vs. （16.59± 3.37） d, （9.39±3.62） d vs. （14.17±2.54）d] （P〈0.05）. The serum gastrin levels in artificial defecation were significantly higher than those of control group. Conclusion The artificial defecation could increase gastrin secretion and decrease the occurrence of feeding intolerance.

关 键 词：人工通便 早产儿 喂养不耐受 胃泌素水平 

分 类 号：R722.6[医药卫生—儿科]