天然组氨酸衍生的新型手性氨基醇的合成与表征  

SYNTHESIS AND CHARACTERIZATION OF NOVEL CHIRAL AMINO ALCOHOLS DERIVED FROM NATURAL HISTIDINE

作　　者：温集武[1] 周小春[1] 胡荣华[1] 

机构地区：[1]井冈山大学化学化工学院,江西吉安343009

出　　处：《井冈山大学学报（自然科学版）》2010年第3期35-37,57,共4页Journal of Jinggangshan University (Natural Science)

基　　金：江西省教育厅科技计划项目(GJJ09331);井冈山大学博士科研启动基金

摘　　要：手性氨基醇是一类重要的生物活性物质或合成中间体,本文报道从天然组氨酸出发用格氏试剂法合成新的手性氨基醇1,并在1的基础上合成了三个氨基单取代的氨基醇2-4,分子结构通过1H-NMR、13C-NMR和元素分析等手段进行了表征。Chiral amino alcohol is an important category of substances with biological activity or synthetic intermediates. In this paper, a novel chiral amino alcohol 1 has been synthesized from natural histidine by Grignard reaction. The amino-monosubstituted derivatives 2-4 were also synthesized from 1 by a convenient route. All of the molecular structures of chiral amino alcohols were characterized by 1H-NMR, 13C-NMR and elemental analysis.

关 键 词：手性氨基醇 组氨酸 合成 表征 

分 类 号：O623.734[理学—有机化学]