糖尿病肾病合并高血压患者血清转化生长因子及相关指标的变化  

Changes of transforming growth factor-β_1 (TGF-β_1) and other relative factors in type 2 diabetic patients with nephropathy and hypertension

作　　者：叶春芳[1] 李树民[2] 王晓丽[3] 陈冬[2] 

机构地区：[1]河北省唐山市人民医院内分泌病科,063000 [2]华北煤炭医学院 [3]河北省唐山市疾病预防控制中心

出　　处：《江苏医药》2010年第9期1035-1037,共3页Jiangsu Medical Journal

摘　　要：目的探讨糖尿病肾病(DN)合并高血压患者血清转化生长因子-β1(TGF-β1)的变化及其与相关指标的关系。方法 123例2型糖尿病(T2DM)合并DN患者分为DN组(61例)、DN合并高血压组(DNH组,62例);另选原发性高血压患者作为对照(C组,45例)。采用双抗体夹心酶联免疫法测定血清TGF-β1水平。尿白蛋白排泄率(UAER)、血管紧张素Ⅱ(AngⅡ)。结果 DNH组血清TGF-β1含量明显高于C组及DN组(P<0.05),TGF-β1与UAER、AngⅡ存在显著正相关关系。结论血清TGF-β1含量随DN的发生和进展而增高,对于监测糖尿病肾病的发生和发展有重要意义。Objective To investigate the changes of transforming growth factor-β1（TGF-β1） and relationship with other relative factors in type 2 diabetic patients （T2DM） with nephropathy（DN） and hypertension.Methods Serum TGF-β1 was measured with ELISA in 123 patients with T2DM,who were divided into two groups of DN（61 cases） and DNH（62 DN cases with hypertension）.Another 45 patients with essential hypertension were taken as the controls（group C）.Urinary albumin excretion rate（UAER） and angiotonin Ⅱ（Ang Ⅱ） were examined as well.ResultsSerum level of TGF-β1 was significantly higher in group DNH than that in groups of DN and C（P〈0.05）.Serum level of TGF-β1 was positively correlated to UAER and Ang Ⅱ.Conclusion Serum level of TGF-β1 increases as DN progresses,which plays an important role in development and progression of DN.

关 键 词：糖尿病肾病 转化生长因子 高血压 血管紧张素Ⅱ 

分 类 号：R587[医药卫生—内分泌]