多囊卵巢综合征患者下丘脑-垂体-肾上腺轴改变与胰岛素抵抗的关系  

Relation between hypothalamic-pituitary-adrenal axis activity and insulin resistance in woman with polycystic ovary syndrome

作　　者：陶弢[1] 刘伟[1] 杨洁谨[1] 毛秀英[1] 成琦[1] 周佳雯[1] 陈雅雯[1] 

机构地区：[1]上海交通大学医学院附属仁济医院内分泌科,200127

出　　处：《中华内分泌代谢杂志》2010年第5期368-369,共2页Chinese Journal of Endocrinology and Metabolism

摘　　要：观察40例多囊卵巢综合征（PCOS）患者基础血和尿皮质醇、垂体激素、稳态模型评估的胰岛素抵抗指数（HOMA—IR）及0．25mg地塞米松抑制试验后血皮质醇的变化。超重／肥胖的PCOS患者基础和抑制试验后皮质醇水平均升高（P〈0．05或P〈0．01），提示其糖皮质激素的负反馈调节机制受损，其下丘脑-垂体-肾上腺轴改变与胰岛素抵抗相关。Forty women with polycystic ovary syndrome （PCOS）were enrolled. Basal plasma and urine cortisol,pituitary hormones, homeostasis model assessment for insulin resistance, and plasma cortisol in 0.25 mg dexamethasone inhibition test were determined. In over-weight or obese PCOS patients, cortisol levels before and after inhibition test were increased （P〈0.05 or P〈0.01 ）. The results suggest that the feed-back regulation of glucocorticoids to hypothalamas-pituitary is impaired and the change in hypothalamic-pituitary-adrenal axis is associated with insulin resistance.

关 键 词：多囊卵巢综合征 胰岛素抵抗 下丘脑-垂体-肾上腺轴 皮质醇 

分 类 号：R711.75[医药卫生—妇产科学]