荧光磁性微球Fe_3O_4@PHEMA-Eu的制备、表征及其载药性研究  

Study on Preparation,Characterization and Drug Loading Properties of Fluorescent-magnetic Bifunctional Microspheres Fe_3O_4@PHEMA-Eu

作　　者：孟繁宗[1,2] 焦志峰[3] 翟玉春[1] 

机构地区：[1]东北大学材料与冶金学院,辽宁沈阳110004 [2]德州学院先进材料研究所,山东德州253023 [3]南阳医学高等专科学校分析检测实验室,河南南阳473058

出　　处：《稀土》2010年第1期1-6,共6页Chinese Rare Earths

基　　金：山东省自然科学基金项目资助(Q2006F01)

摘　　要：在亲水性Fe3O4磁流体中,以甲基丙烯酸-2-羟基乙酯(HEMA)为单体,N,N’-亚甲基双丙烯酰胺(MBA)为交联剂,采用光化学方法在水溶液体系中首先合成磁性聚甲基丙烯酸-2-羟基乙酯(PHEMA)微球,进而在60℃下PHEMA与Eu离子反应合成具有荧光特性的磁性微球(FMPMs),同时用丝裂霉素C(MMC)考查了其载药性。运用VSM、PCS、FTIR、TGA、SEM、FS、HPLC等技术对微球的性能进行了表征。结果表明,荧光磁性高分子微球有超顺磁性,荧光性,呈很好的球形,载药率和包裹率较高。Taking the 2-hydroxyethyl methacrylate as a monomer,and N,N＇methyl radical double acrylics amide as a cross linking agent,magnetic nanometer particles consisting of hydroxyl radicals were prepared by photochemistry synthesis in hydrophilicmagnetic fluid Fe3O4.Then,fluorescent magnetic polymer microspheres（FMPMs） containing Eu were synthesized,and their drug loading properties were examined usingMitomycin C.The magnetic,structural,morphological,fluorescent and drug loading properties of FMPMs were characterrized by VSM,PCS,FTIR,TG,SEM,FS and HPLC.The results indicated that the FMPMs were superparamagnetic,well shaped and narrow-sized particles with abundant hydroxyl and large drug loading amount.

关 键 词：荧光磁性高分子微球 甲基丙烯酸-2-羟基乙酯 光化学合成 制备 表征 载药性 

分 类 号：O632[理学—高分子化学] O482.31[理学—化学]